ID   H7BZ94_HUMAN            Unreviewed;       464 AA.
AC   H7BZ94;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 2.
DT   16-JAN-2019, entry version 54.
DE   SubName: Full=Protein disulfide-isomerase {ECO:0000313|Ensembl:ENSP00000388374};
GN   Name=P4HB {ECO:0000313|Ensembl:ENSP00000388374};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000388374, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000388374, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0000313|Ensembl:ENSP00000388374}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
RN   [4] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
RN   [5] {ECO:0000213|PubMed:25944712}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25944712;
RA   Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
RA   Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT   "N-terminome analysis of the human mitochondrial proteome.";
RL   Proteomics 15:2519-2524(2015).
CC   -!- SIMILARITY: Belongs to the protein disulfide isomerase family.
CC       {ECO:0000256|RuleBase:RU004208, ECO:0000256|SAAS:SAAS00569802}.
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DR   EMBL; AC145207; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC174470; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H7BZ94; -.
DR   SMR; H7BZ94; -.
DR   EPD; H7BZ94; -.
DR   jPOST; H7BZ94; -.
DR   MaxQB; H7BZ94; -.
DR   PeptideAtlas; H7BZ94; -.
DR   PRIDE; H7BZ94; -.
DR   Ensembl; ENST00000439918; ENSP00000388374; ENSG00000185624.
DR   UCSC; uc060loc.1; human.
DR   EuPathDB; HostDB:ENSG00000185624.14; -.
DR   HGNC; HGNC:8548; P4HB.
DR   OpenTargets; ENSG00000185624; -.
DR   GeneTree; ENSGT00940000157351; -.
DR   ChiTaRS; P4HB; human.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000185624; Expressed in 235 organ(s), highest expression level in right lobe of liver.
DR   ExpressionAtlas; H7BZ94; baseline and differential.
DR   GO; GO:0005783; C:endoplasmic reticulum; IDA:HPA.
DR   GO; GO:0016853; F:isomerase activity; IEA:InterPro.
DR   GO; GO:0045454; P:cell redox homeostasis; IEA:InterPro.
DR   InterPro; IPR005788; Disulphide_isomerase.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   InterPro; IPR017937; Thioredoxin_CS.
DR   InterPro; IPR013766; Thioredoxin_domain.
DR   Pfam; PF00085; Thioredoxin; 1.
DR   SUPFAM; SSF52833; SSF52833; 4.
DR   TIGRFAMs; TIGR01126; pdi_dom; 2.
DR   PROSITE; PS00194; THIOREDOXIN_1; 2.
DR   PROSITE; PS51352; THIOREDOXIN_2; 2.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00903405};
KW   Proteomics identification {ECO:0000213|EPD:H7BZ94,
KW   ECO:0000213|MaxQB:H7BZ94, ECO:0000213|PeptideAtlas:H7BZ94};
KW   Redox-active center {ECO:0000256|SAAS:SAAS00903442};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00435042};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     17       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        18    464       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003608316.
FT   DOMAIN        8    190       Thioredoxin.
FT                                {ECO:0000259|PROSITE:PS51352}.
FT   DOMAIN      305    431       Thioredoxin.
FT                                {ECO:0000259|PROSITE:PS51352}.
SQ   SEQUENCE   464 AA;  52502 MW;  5A9AD45C0CA46796 CRC64;
     MLRRALLCLA VAALVRADAP EEEDHVLVLR KSNFAEALAA HKYLLVEFYA PWCGHCKALA
     PEYAKAAGKL KAEGSEIRLA KVDATEESDL AQQYGVRGYP TIKFFRNGDT ASPKEYTGDV
     ESDSAKQFLQ AAEAIDDIPF GITSNSDVFS KYQLDKDGVV LFKKFDEGRN NFEGEVTKEN
     LLDFIKHNQL PLVIEFTEQT APKIFGGEIK THILLFLPKS VSDYDGKLSN FKTAAESFKG
     KILFIFIDSD HTDNQRILEF FGLKKEECPA VRLITLEEEM TKYKPESEEL TAERITEFCH
     RFLEGKIKPH LMSQELPEDW DKQPVKVLVG KNFEDVAFDE KKNVFVEFYA PWCGHCKQLA
     PIWDKLGETY KDHENIVIAK MDSTANEVEA VKVHSFPTLK FFPASADRTV IDYNGERTLD
     GFKKFLESGG QDGAGDDDDL EDLEEAEEPD MEEDDDQKAV KDEL
//