ID   H7BZ16_HUMAN            Unreviewed;       255 AA.
AC   H7BZ16;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   16-JAN-2019, entry version 31.
DE   SubName: Full=All-trans-retinol 13,14-reductase {ECO:0000313|Ensembl:ENSP00000387196};
DE   Flags: Fragment;
GN   Name=RETSAT {ECO:0000313|Ensembl:ENSP00000387196};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000387196, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000387196, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0000313|Ensembl:ENSP00000387196}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
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DR   EMBL; AC062037; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC093162; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H7BZ16; -.
DR   EPD; H7BZ16; -.
DR   jPOST; H7BZ16; -.
DR   MaxQB; H7BZ16; -.
DR   PeptideAtlas; H7BZ16; -.
DR   PRIDE; H7BZ16; -.
DR   Ensembl; ENST00000409984; ENSP00000387196; ENSG00000042445.
DR   UCSC; uc061lfi.1; human.
DR   EuPathDB; HostDB:ENSG00000042445.13; -.
DR   HGNC; HGNC:25991; RETSAT.
DR   OpenTargets; ENSG00000042445; -.
DR   eggNOG; KOG4254; Eukaryota.
DR   eggNOG; COG1233; LUCA.
DR   GeneTree; ENSGT00390000017613; -.
DR   ChiTaRS; RETSAT; human.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; ENSG00000042445; Expressed in 222 organ(s), highest expression level in adipose tissue.
DR   ExpressionAtlas; H7BZ16; baseline and differential.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   SUPFAM; SSF51905; SSF51905; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:H7BZ16,
KW   ECO:0000213|MaxQB:H7BZ16, ECO:0000213|PeptideAtlas:H7BZ16};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19    255       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003608427.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSP00000387196}.
FT   NON_TER     255    255       {ECO:0000313|Ensembl:ENSP00000387196}.
SQ   SEQUENCE   255 AA;  28048 MW;  8318DAE86A97999B CRC64;
     XWLPLVLLLA VLLLAVLCKV YLGLFSGSSP NPFSEDVKRP PAPLVTDKEA RKKVLKQGIH
     YIGRMEEGSI GRFILDQITE GQLDWAPLSS PFDIMVLEGP NGRKEYPMYS GEKAYIQGLK
     EKFPQEEAII DKYIKLVKVV SSGAPHAILL KFLPLPVVQL LDRCGLLTRF SPFLQASTQS
     LAEVLQQLGA SSELQAVLSY IFPTYGVTPN HSAFSMHALL VNHYMKGGFY PRGGSSEIAF
     HTIPVIQRAG GAVLT
//