ID   H7BYX7_HUMAN            Unreviewed;      1446 AA.
AC   H7BYX7;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   12-SEP-2018, entry version 37.
DE   SubName: Full=Phospholipase B1, membrane-associated {ECO:0000313|Ensembl:ENSP00000384187};
DE   Flags: Fragment;
GN   Name=PLB1 {ECO:0000313|Ensembl:ENSP00000384187};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000384187, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000384187, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000384187}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
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DR   EMBL; AC074011; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC093164; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC104695; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF510808; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H7BYX7; -.
DR   PeptideAtlas; H7BYX7; -.
DR   PRIDE; H7BYX7; -.
DR   Ensembl; ENST00000404858; ENSP00000384187; ENSG00000163803.
DR   UCSC; uc061hsi.1; human.
DR   EuPathDB; HostDB:ENSG00000163803.12; -.
DR   HGNC; HGNC:30041; PLB1.
DR   OpenTargets; ENSG00000163803; -.
DR   eggNOG; KOG3670; Eukaryota.
DR   eggNOG; ENOG4111FH4; LUCA.
DR   GeneTree; ENSGT00530000063883; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; ENSG00000163803; Expressed in 96 organ(s), highest expression level in blood.
DR   ExpressionAtlas; H7BYX7; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004620; F:phospholipase activity; IEA:InterPro.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR   CDD; cd01824; Phospholipase_B_like; 4.
DR   Gene3D; 3.40.50.1110; -; 2.
DR   InterPro; IPR001087; GDSL.
DR   InterPro; IPR008265; Lipase_GDSL_AS.
DR   InterPro; IPR035547; Phospholipase_B.
DR   InterPro; IPR038885; PLB1.
DR   InterPro; IPR036514; SGNH_hydro_sf.
DR   PANTHER; PTHR21325; PTHR21325; 4.
DR   Pfam; PF00657; Lipase_GDSL; 3.
DR   PROSITE; PS01098; LIPASE_GDSL_SER; 2.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:H7BYX7};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21   1446       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003608426.
FT   TRANSMEM   1403   1426       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      404    656       Lipase_GDSL. {ECO:0000259|Pfam:PF00657}.
FT   DOMAIN      729   1003       Lipase_GDSL. {ECO:0000259|Pfam:PF00657}.
FT   DOMAIN     1085   1349       Lipase_GDSL. {ECO:0000259|Pfam:PF00657}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSP00000384187}.
SQ   SEQUENCE   1446 AA;  161636 MW;  8FBCC6C5A71A7D92 CRC64;
     XLRPGIFLLE LLLLLGQGTP QIHTSPRKST LEGQLWPETL KNSPFPCNPN KLGVNMPSKS
     VHSLKPSDIK FVAAIGNLEI PPDPGTGDLE KQDWTERPQQ VCMGVMTVLS DIIRYFSPSV
     PMPVCHTGKR VIPHDGAEDL WIQAQELVRN MKENLQLDFQ FDWKLINVFF SNASQCYLCP
     SAQQAPSLST VLLSQNGLAA GGVDELMGVL DYLQQEVPRA FVNLVDLSEV AEVSRQYHGT
     WLSPAPEPCN CSEETTRLAK VVMQWSYQEA WNSLLASSRY SEQESFTVVF QPFFYETTPS
     LHSEDPRLQD STTLAWHLWN RMMEPAGEKD EPLSVKHGRP MKCPSQESPY LFSYRNSNYL
     TRLQKPQDKL EVREGAEIRC PDKDPSDTVP TSVHRLKPAD INVIGALGDS LTAGNGAGST
     PGNVLDVLTQ YRGLSWSVGG DENIGTVTTL ANILREFNPS LKGFSVGTGK ETSPNAFLNQ
     AVAGGRAEDL PVQARRLVDL MKNDTRIHFQ EDWKIITLFI GGNDLCDFCN DLVPRAFVNL
     VTVLEIVNLR ELYQEKKVYC PRMILRSLCP CVLKFDDNST ELATLIEFNK KFQEKTHQLI
     ESGRYDTRED FTVVVQPFFE NVDMPKTSEG LPDNSFFAPD CFHFSSKSHS RAASALWNNM
     LEPVGQKTTR HKFENKINIT CPNQVQPFLR TYKNSMQGHG TWLPCRDRAP SALHPTSVHA
     LRPADIQVVA ALGDSLTAGN GIGSKPDDLP DVTTQYRGLS YSAGGDGSLE NVTTLPNILR
     EFNRNLTGYA VGTGDANDTN AFLNQAVPGA KAEDLMSQVQ TLMQKMKDDH RVNFHEDWKV
     ITVLIGGSDL CDYCTDSNLY SAANFVHHLR NALDVLHREV PRVLVNLVDF LNPTIMRQVF
     LGNPDKCPVQ QASVLCNCVL TLRENSQELA RLEAFSRAYR SSMRELVGSG RYDTQEDFSV
     VLQPFFQNIQ LPVLADGLPD TSFFAPDCIH PNQKFHSQLA RALWTNMLEP LGSKTETLDL
     RAEMPITCPT QNEPFLRTPR NSNYTYPIKP AIENWGSDFL CTEWKASNSV PTSVHQLRPA
     DIKVVAALGD SLTTAVGARP NNSSDLPTSW RGLSWSIGGD GNLETHTTLP NILKKFNPYL
     LGFSTSTWEG TAGLNVAAEG ARARDMPAQA WDLVERMKNS PDINLEKDWK LVTLFIGVND
     LCHYCENPEA HLATEYVQHI QQALDILSEE LPRAFVNVVE VMELASLYQG QGGKCAMLAA
     QNNCTCLRHS QSSLEKQELK KVNWNLQHGI SSFSYWHQYT QREDFAVVVQ PFFQNTLTPL
     NERGDTDLTF FSEDCFHFSD RGHAEMAIAL WNNMLEPVGR KTTSNNFTHS RAKLKCPSPE
     SPYLYTLRNS RLLPDQAEEA PEVLYWAVPV AAGVGLVVGI IGTVVWRCRR GGRREDPPMS
     LRTVAL
//