ID   H7BY08_HUMAN            Unreviewed;       241 AA.
AC   H7BY08;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 2.
DT   05-DEC-2018, entry version 41.
DE   SubName: Full=Disintegrin and metalloproteinase domain-containing protein 11 {ECO:0000313|Ensembl:ENSP00000347856};
GN   Name=ADAM11 {ECO:0000313|Ensembl:ENSP00000347856};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000347856, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000347856, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000347856}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
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DR   EMBL; AC005180; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H7BY08; -.
DR   PeptideAtlas; H7BY08; -.
DR   Ensembl; ENST00000355638; ENSP00000347856; ENSG00000073670.
DR   UCSC; uc060gbs.1; human.
DR   EuPathDB; HostDB:ENSG00000073670.13; -.
DR   HGNC; HGNC:189; ADAM11.
DR   OpenTargets; ENSG00000073670; -.
DR   eggNOG; KOG3607; Eukaryota.
DR   eggNOG; ENOG410XX2M; LUCA.
DR   GeneTree; ENSGT00940000159790; -.
DR   ChiTaRS; ADAM11; human.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000073670; Expressed in 157 organ(s), highest expression level in right hemisphere of cerebellum.
DR   ExpressionAtlas; H7BY08; baseline and differential.
DR   InterPro; IPR002870; Peptidase_M12B_N.
DR   Pfam; PF01562; Pep_M12B_propep; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:H7BY08};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24    241       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003609141.
FT   DOMAIN       60    189       Pep_M12B_propep.
FT                                {ECO:0000259|Pfam:PF01562}.
SQ   SEQUENCE   241 AA;  26096 MW;  800088FE0A0AC1B4 CRC64;
     MRLLRRWAFA ALLLSLLPTP GLGTQGPAGA LRWGGLPQLG GPGAPEVTEP SRLVRESSGG
     EVRKQQLDTR VRQEPPGGPP VHLAQVSFVI PAFNSNFTLD LELNHHLLSS QYVERHFSRE
     GTTQHSTGAG DHCYYQGKLR GNPHSFAALS TCQGLHGVFS DGNLTYIVEP QEVAGPWGAP
     QGPLPHLIYR TPLLPDPLGC REPGCLFAVP AQSAPPNRPR LRRKRSAGAT LQCTVKPSMW
     S
//