ID H7BXT0_HUMAN Unreviewed; 231 AA. AC H7BXT0; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 16-JAN-2019, entry version 50. DE SubName: Full=Vitamin K-dependent protein S {ECO:0000313|Ensembl:ENSP00000330021}; DE Flags: Fragment; GN Name=PROS1 {ECO:0000313|Ensembl:ENSP00000330021}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000330021, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000330021, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16641997; DOI=10.1038/nature04728; RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., RA Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., RA Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., RA Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., RA Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., RA Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S., RA Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., RA Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., RA Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., RA Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., RA Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., RA Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., RA Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., RA Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A., RA Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., RA Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J., RA Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., RA Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., RA Gibbs R.A.; RT "The DNA sequence, annotation and analysis of human chromosome 3."; RL Nature 440:1194-1198(2006). RN [2] {ECO:0000313|Ensembl:ENSP00000330021} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. RN [3] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC117474; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC144562; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H7BXT0; -. DR SMR; H7BXT0; -. DR jPOST; H7BXT0; -. DR PeptideAtlas; H7BXT0; -. DR PRIDE; H7BXT0; -. DR Ensembl; ENST00000348974; ENSP00000330021; ENSG00000184500. DR UCSC; uc062lsx.1; human. DR EuPathDB; HostDB:ENSG00000184500.14; -. DR HGNC; HGNC:9456; PROS1. DR OpenTargets; ENSG00000184500; -. DR ChiTaRS; PROS1; human. DR Proteomes; UP000005640; Chromosome 3. DR Bgee; ENSG00000184500; Expressed in 227 organ(s), highest expression level in choroid plexus epithelium. DR ExpressionAtlas; H7BXT0; baseline and differential. DR GO; GO:0005576; C:extracellular region; IEA:InterPro. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR GO; GO:0030195; P:negative regulation of blood coagulation; IEA:InterPro. DR Gene3D; 4.10.740.10; -; 1. DR InterPro; IPR017857; Coagulation_fac-like_Gla_dom. DR InterPro; IPR001881; EGF-like_Ca-bd_dom. DR InterPro; IPR013032; EGF-like_CS. DR InterPro; IPR000742; EGF-like_dom. DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site. DR InterPro; IPR018097; EGF_Ca-bd_CS. DR InterPro; IPR035972; GLA-like_dom_SF. DR InterPro; IPR000294; GLA_domain. DR InterPro; IPR033189; PROS1. DR PANTHER; PTHR24040:SF0; PTHR24040:SF0; 1. DR Pfam; PF00008; EGF; 1. DR Pfam; PF00594; Gla; 1. DR PRINTS; PR00001; GLABLOOD. DR SMART; SM00181; EGF; 2. DR SMART; SM00179; EGF_CA; 2. DR SMART; SM00069; GLA; 1. DR SUPFAM; SSF57630; SSF57630; 1. DR PROSITE; PS00010; ASX_HYDROXYL; 1. DR PROSITE; PS00022; EGF_1; 1. DR PROSITE; PS01186; EGF_2; 1. DR PROSITE; PS50026; EGF_3; 1. DR PROSITE; PS01187; EGF_CA; 1. DR PROSITE; PS00011; GLA_1; 1. DR PROSITE; PS50998; GLA_2; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076, KW ECO:0000256|SAAS:SAAS00601599}; KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076, KW ECO:0000256|SAAS:SAAS00602928}; Membrane {ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|MaxQB:H7BXT0, KW ECO:0000213|PeptideAtlas:H7BXT0}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 231 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003608272. FT TRANSMEM 34 54 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 73 119 Gla. {ECO:0000259|PROSITE:PS50998}. FT DOMAIN 149 187 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DISULFID 158 175 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 177 186 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT NON_TER 231 231 {ECO:0000313|Ensembl:ENSP00000330021}. SQ SEQUENCE 231 AA; 25893 MW; E2CEC8AE25618010 CRC64; MRVLGGRCGA LLACLLLVLP VSEANFCLYF RNDFIYNRAC ISVLVGLSGC NFFYSICFLS KQQASQVLVR KRRANSLLEE TKQGNLEREC IEELCNKEEA REVFENDPET DYFYPKYLVC LRSFQTGLFT AARQSTNAYP DLRSCVNAIP DQCSPLPCNE DGYMSCKDGK ASFTCTCKPG WQGEKCEFDI NECKDPSNIN GGCSQICDNT PGSYHCSCKN GFVMLSNKKD C //