ID H7BXJ2_HUMAN Unreviewed; 884 AA. AC H7BXJ2; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 16-JAN-2019, entry version 55. DE SubName: Full=Netrin receptor UNC5D {ECO:0000313|Ensembl:ENSP00000287272}; GN Name=UNC5D {ECO:0000313|Ensembl:ENSP00000287272}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000287272, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000287272, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16421571; DOI=10.1038/nature04406; RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., RA Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., RA Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., RA Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T., RA Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., RA DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Glockner G., RA Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., RA Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., RA O'Leary S.B., O'Neill K., Parker S.C., Polley A., Raymond C.K., RA Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., RA Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., RA Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., RA Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., RA Lander E.S.; RT "DNA sequence and analysis of human chromosome 8."; RL Nature 439:331-335(2006). RN [2] {ECO:0000313|Ensembl:ENSP00000287272} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC012215; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC013302; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC090740; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC099685; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC104049; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC105230; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_011542706.1; XM_011544404.2. DR UniGene; Hs.238889; -. DR UniGene; Hs.720206; -. DR ProteinModelPortal; H7BXJ2; -. DR EPD; H7BXJ2; -. DR PeptideAtlas; H7BXJ2; -. DR PRIDE; H7BXJ2; -. DR Ensembl; ENST00000287272; ENSP00000287272; ENSG00000156687. DR GeneID; 137970; -. DR UCSC; uc022atw.2; human. DR CTD; 137970; -. DR EuPathDB; HostDB:ENSG00000156687.10; -. DR HGNC; HGNC:18634; UNC5D. DR OpenTargets; ENSG00000156687; -. DR GeneTree; ENSGT00940000153287; -. DR OrthoDB; 334938at2759; -. DR ChiTaRS; UNC5D; human. DR GenomeRNAi; 137970; -. DR Proteomes; UP000005640; Chromosome 8. DR Bgee; ENSG00000156687; Expressed in 103 organ(s), highest expression level in forebrain. DR ExpressionAtlas; H7BXJ2; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005042; F:netrin receptor activity; IEA:InterPro. DR Gene3D; 2.20.100.10; -; 1. DR Gene3D; 2.60.40.10; -; 2. DR InterPro; IPR011029; DEATH-like_dom_sf. DR InterPro; IPR000488; Death_domain. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR013098; Ig_I-set. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR000884; TSP1_rpt. DR InterPro; IPR036383; TSP1_rpt_sf. DR InterPro; IPR037936; UNC5. DR InterPro; IPR033772; UPA. DR InterPro; IPR000906; ZU5_dom. DR PANTHER; PTHR12582; PTHR12582; 2. DR Pfam; PF00531; Death; 1. DR Pfam; PF07679; I-set; 1. DR Pfam; PF17217; UPA; 1. DR Pfam; PF00791; ZU5; 1. DR SMART; SM00005; DEATH; 1. DR SMART; SM00409; IG; 1. DR SMART; SM00408; IGc2; 1. DR SMART; SM00209; TSP1; 1. DR SMART; SM00218; ZU5; 1. DR SUPFAM; SSF47986; SSF47986; 1. DR SUPFAM; SSF48726; SSF48726; 2. DR SUPFAM; SSF82895; SSF82895; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS50092; TSP1; 1. DR PROSITE; PS51145; ZU5; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|PeptideAtlas:H7BXJ2}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 32 {ECO:0000256|SAM:SignalP}. FT CHAIN 33 884 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003609133. FT TRANSMEM 324 347 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 166 244 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 473 613 ZU5. {ECO:0000259|PROSITE:PS51145}. SQ SEQUENCE 884 AA; 98305 MW; ACA072DFED1A5A5F CRC64; MGRAAATAGG GGGARRWLPW LGLCFWAAGT AAARGTDNGE ALPESIPSAP GTLPHFIEEP DDAYIIKSNP IALRCKARPA MQIFFKCNGE WVHQNEHVSE ETLDESSGLK VREVFINVTR QQVEDFHGPE DYWCQCVAWS HLGTSKSRKA SVRIAYLRKN FEQDPQGREV PIEGMIVLHC RPPEGVPAAE VEWLKNEEPI DSEQDENIDT RADHNLIIRQ ARLSDSGNYT CMAANIVAKR RSLSATVVVY VDGSWEVWSE WSVCSPECEH LRIRECTAPP PRNGGKFCEG LSQESENCTD GLCILDKKPL HEIKPQSIEN ASDIALYSGL GAAVVAVAVL VIGVTLYRRS QSDYGVDVID SSALTGNSLL LNSAMQPDLT VSRTYSGPIC LQDPLDKELM TESSLFNPLS DIKVKVQSSF MVSLGVSERA EYHGKNHSRT FPHGNNHSFS TMHPRNKMPY IQNLSSLPTR TELRTTGVFG HLGGRLVMPN TGVSLLIPHG AIPEENSWEI YMSINQGEPS LQSDGSEVLL SPEVTCGPPD MIVTTPFALT IPHCADVSSE HWNIHLKKRT QQGKWEEVMS VEDESTSCYC LLDPFACHVL LDSFGTYALT GEPITDCAVK QLKVAVFGCM SCNSLDYNLR VYCVDNTPCA FQEVVSDERH QGGQLLEEPK LLHFKGNTFS LQISVLDIPP FLWRIKPFTA CQEVPFSRVW CSNRQPLHCA FSLERYTPTT TQLSCKICIR QLKGHEQILQ VQTSILESER ETITFFAQED STFPAQTGPK AFKIPYSIRQ RICATFDTPN AKGKDWQMLA QKNSINRNLS YFATQSSPSA VILNLWEARH QHDGDLDSLA CALEEIGRTH TKLSNISESQ LDEADFNYSR QNGL //