ID   H3BVI7_HUMAN            Unreviewed;       414 AA.
AC   H3BVI7;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   16-JAN-2019, entry version 49.
DE   SubName: Full=Cadherin-1 {ECO:0000313|Ensembl:ENSP00000458139};
GN   Name=CDH1 {ECO:0000313|Ensembl:ENSP00000458139};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000458139, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000458139, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15616553; DOI=10.1038/nature03187;
RA   Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X.,
RA   Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A.,
RA   Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.,
RA   Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L.,
RA   Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A.,
RA   Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D.,
RA   Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J.,
RA   Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA   Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I.,
RA   Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W.,
RA   Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A.,
RA   Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S.,
RA   Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA   Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA   Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L.,
RA   Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A.,
RA   Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L.,
RA   Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N.,
RA   Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M.,
RA   Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L.,
RA   Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D.,
RA   Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P.,
RA   Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M.,
RA   Rubin E.M., Pennacchio L.A.;
RT   "The sequence and analysis of duplication-rich human chromosome 16.";
RL   Nature 432:988-994(2004).
RN   [2] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0000313|Ensembl:ENSP00000458139}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
RN   [4] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|SAAS:SAAS01075634}; Single-pass type I membrane
CC       protein {ECO:0000256|SAAS:SAAS01075634}.
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DR   EMBL; AC099314; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H3BVI7; -.
DR   jPOST; H3BVI7; -.
DR   MaxQB; H3BVI7; -.
DR   PeptideAtlas; H3BVI7; -.
DR   PRIDE; H3BVI7; -.
DR   Ensembl; ENST00000566510; ENSP00000458139; ENSG00000039068.
DR   UCSC; uc059wia.1; human.
DR   EuPathDB; HostDB:ENSG00000039068.18; -.
DR   HGNC; HGNC:1748; CDH1.
DR   OpenTargets; ENSG00000039068; -.
DR   GeneTree; ENSGT00940000157175; -.
DR   ChiTaRS; CDH1; human.
DR   Proteomes; UP000005640; Chromosome 16.
DR   Bgee; ENSG00000039068; Expressed in 185 organ(s), highest expression level in jejunal mucosa.
DR   ExpressionAtlas; H3BVI7; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   InterPro; IPR039808; Cadherin.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR020894; Cadherin_CS.
DR   InterPro; IPR014868; Cadherin_pro_dom.
DR   PANTHER; PTHR24027; PTHR24027; 2.
DR   Pfam; PF00028; Cadherin; 2.
DR   Pfam; PF08758; Cadherin_pro; 1.
DR   PRINTS; PR00205; CADHERIN.
DR   SMART; SM00112; CA; 2.
DR   SMART; SM01055; Cadherin_pro; 1.
DR   SUPFAM; SSF49313; SSF49313; 3.
DR   PROSITE; PS00232; CADHERIN_1; 1.
PE   1: Evidence at protein level;
KW   Calcium {ECO:0000256|SAAS:SAAS00020193};
KW   Cell adhesion {ECO:0000256|SAAS:SAAS01075623};
KW   Cell membrane {ECO:0000256|SAAS:SAAS01075618};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAAS:SAAS00616217,
KW   ECO:0000256|SAAS:SAAS01075618};
KW   Metal-binding {ECO:0000256|SAAS:SAAS01075609};
KW   Proteomics identification {ECO:0000213|MaxQB:H3BVI7,
KW   ECO:0000213|PeptideAtlas:H3BVI7};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00436611};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00616217};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00616217}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23    414       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003581080.
FT   DOMAIN       27    116       Cadherin_pro.
FT                                {ECO:0000259|SMART:SM01055}.
FT   DOMAIN       53    208       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      232    321       CA. {ECO:0000259|SMART:SM00112}.
SQ   SEQUENCE   414 AA;  45520 MW;  E25C5BEACFDB7204 CRC64;
     MGPWSRSLSA LLLLLQVSSW LCQEPEPCHP GFDAESYTFT VPRRHLERGR VLGRVNFEDC
     TGRQRTAYFS LDTRFKVGTD GVITVKRPLR FHNPQIHFLV YAWDSTYRKF STKVTLNTVG
     HHHRPPPHQA SVSGIQAELL TFPNSSPGLR RQKRDWVIPP ISCPENEKGP FPKNLVQLFS
     HAVSSNGNAV EDPMEILITV TDQNDNKPEF TQEVFKGSVM EGALPGTSVM EVTATDADDD
     VNTYNAAIAY TILSQDPELP DKNMFTINRN TGVISVVTTG LDRESFPTYT LVVQAADLQG
     EGLSTTATAV ITVTDTNDNP PIFNPTTYKG QVPENEANVV ITTLKVTDAD APNTPAWEAV
     YTILNDDGGQ FVVTTNPVNN DGILKTAKVC MVPGKMQKLA SSQLFIPLSP GLGF
//