ID   H3BVG6_HUMAN            Unreviewed;       562 AA.
AC   H3BVG6;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   16-JAN-2019, entry version 50.
DE   RecName: Full=Tyrosine-protein kinase receptor {ECO:0000256|RuleBase:RU000312};
DE            EC=2.7.10.1 {ECO:0000256|RuleBase:RU000312};
GN   Name=LTK {ECO:0000313|Ensembl:ENSP00000458111};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000458111, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000458111, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16572171; DOI=10.1038/nature04601;
RA   Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA   Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA   Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA   Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA   DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R.,
RA   Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G.,
RA   Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A.,
RA   Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W.,
RA   Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X.,
RA   Sneddon K.M., Stewart S., Sougnez C., Stone S.M., Topham K.,
RA   Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S.,
RA   Nusbaum C.;
RT   "Analysis of the DNA sequence and duplication history of human
RT   chromosome 15.";
RL   Nature 440:671-675(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000458111}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-
CC         tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136,
CC         Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216;
CC         EC=2.7.10.1; Evidence={ECO:0000256|RuleBase:RU000312};
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC       kinase family. Insulin receptor subfamily.
CC       {ECO:0000256|RuleBase:RU000312}.
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DR   EMBL; AC016134; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC087721; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H3BVG6; -.
DR   PeptideAtlas; H3BVG6; -.
DR   PRIDE; H3BVG6; -.
DR   Ensembl; ENST00000561619; ENSP00000458111; ENSG00000062524.
DR   UCSC; uc010bcg.3; human.
DR   EuPathDB; HostDB:ENSG00000062524.15; -.
DR   HGNC; HGNC:6721; LTK.
DR   OpenTargets; ENSG00000062524; -.
DR   eggNOG; KOG1095; Eukaryota.
DR   eggNOG; ENOG410XPVX; LUCA.
DR   GeneTree; ENSGT00940000162680; -.
DR   Proteomes; UP000005640; Chromosome 15.
DR   Bgee; ENSG00000062524; Expressed in 98 organ(s), highest expression level in mucosa of transverse colon.
DR   ExpressionAtlas; H3BVG6; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:InterPro.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR008266; Tyr_kinase_AS.
DR   InterPro; IPR020635; Tyr_kinase_cat_dom.
DR   InterPro; IPR002011; Tyr_kinase_rcpt_2_CS.
DR   Pfam; PF07714; Pkinase_Tyr; 1.
DR   PRINTS; PR00109; TYRKINASE.
DR   SMART; SM00219; TyrKc; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR   PROSITE; PS00239; RECEPTOR_TYR_KIN_II; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Phosphoprotein {ECO:0000256|RuleBase:RU000312};
KW   Receptor {ECO:0000256|RuleBase:RU000312};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19    562       Tyrosine-protein kinase receptor.
FT                                {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003580714.
FT   TRANSMEM    107    130       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      208    484       Protein kinase.
FT                                {ECO:0000259|PROSITE:PS50011}.
SQ   SEQUENCE   562 AA;  62157 MW;  4E9A4C8949A6EC5B CRC64;
     MGCWGQLLVW FGAAGGDASE TDNLWADGED GVSFIHPSSE LFLQPLAVTE NHGEVEIRRH
     LNCSHCPLRD CQWQAELQLA ECLCPEGMEL AVDNVTCMDL HKPPGPLVLM VAVVATSTLS
     LLMVCGVLIL GTKRLAGTVD SRLLLSMKQK KWQGLQEMRL PSPELELSKL RTSAIRTAPN
     PYYCQVGLGP AQSWPLPPGV TEVSPANVTL LRALGHGAFG EVYEGLVIGL PGDSSPLQVA
     IKTLPELCSP QDELDFLMEA LIISKFRHQN IVRCVGLSLR ATPRLILLEL MSGGDMKSFL
     RHSRPHLGQP SPLVMRDLLQ LAQDIAQGCH YLEENHFIHR DIAARNCLLS CAGPSRVAKI
     GDFGMARDIY RASYYRRGDR ALLPVKWMPP EAFLEGIFTS KTDSWSFGVL LWEIFSLGYM
     PYPGRTNQEV LDFVVGGGRM DPPRGCPGPV YRIMTQCWQH EPELRPSFAS ILERLQYCTQ
     DPDVLNSLLP MELGPTPEEE GTSGLGNRSL ECLRPPQPQE LSPEKLKSWG GSPLGPWLSS
     GLKPLKSRGL QPQNLWNPTY RS
//