ID   H3BUN7_HUMAN            Unreviewed;       200 AA.
AC   H3BUN7;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   05-DEC-2018, entry version 37.
DE   SubName: Full=SH2B adapter protein 1 {ECO:0000313|Ensembl:ENSP00000457724};
DE   Flags: Fragment;
GN   Name=SH2B1 {ECO:0000313|Ensembl:ENSP00000457724};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000457724, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000457724, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15616553; DOI=10.1038/nature03187;
RA   Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X.,
RA   Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A.,
RA   Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.,
RA   Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L.,
RA   Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A.,
RA   Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D.,
RA   Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J.,
RA   Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA   Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I.,
RA   Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W.,
RA   Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A.,
RA   Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S.,
RA   Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA   Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA   Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L.,
RA   Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A.,
RA   Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L.,
RA   Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N.,
RA   Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M.,
RA   Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L.,
RA   Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D.,
RA   Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P.,
RA   Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M.,
RA   Rubin E.M., Pennacchio L.A.;
RT   "The sequence and analysis of duplication-rich human chromosome 16.";
RL   Nature 432:988-994(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000457724}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AC133550; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H3BUN7; -.
DR   EPD; H3BUN7; -.
DR   PeptideAtlas; H3BUN7; -.
DR   PRIDE; H3BUN7; -.
DR   Ensembl; ENST00000569651; ENSP00000457724; ENSG00000178188.
DR   UCSC; uc059sqb.1; human.
DR   EuPathDB; HostDB:ENSG00000178188.14; -.
DR   HGNC; HGNC:30417; SH2B1.
DR   OpenTargets; ENSG00000178188; -.
DR   eggNOG; ENOG410IMWK; Eukaryota.
DR   eggNOG; ENOG41102PH; LUCA.
DR   GeneTree; ENSGT00940000154061; -.
DR   Proteomes; UP000005640; Chromosome 16.
DR   Bgee; ENSG00000178188; Expressed in 203 organ(s), highest expression level in right hemisphere of cerebellum.
DR   ExpressionAtlas; H3BUN7; baseline and differential.
DR   GO; GO:0035591; F:signaling adaptor activity; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 3.30.505.10; -; 1.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR030523; SH2B.
DR   InterPro; IPR030521; SH2B1.
DR   PANTHER; PTHR10872; PTHR10872; 1.
DR   PANTHER; PTHR10872:SF3; PTHR10872:SF3; 1.
DR   Pfam; PF00017; SH2; 1.
DR   PRINTS; PR00401; SH2DOMAIN.
DR   SMART; SM00252; SH2; 1.
DR   SUPFAM; SSF55550; SSF55550; 1.
DR   PROSITE; PS50001; SH2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:H3BUN7,
KW   ECO:0000213|PeptideAtlas:H3BUN7};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19    200       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003581068.
FT   DOMAIN        2    100       SH2. {ECO:0000259|PROSITE:PS50001}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSP00000457724}.
SQ   SEQUENCE   200 AA;  23193 MW;  B24F6DCA7CF424D1 CRC64;
     XWFHGMLSRL KAAQLVLTGG TGSHGVFLVR QSETRRGEYV LTFNFQGKAK HLRLSLNEEG
     QCRVQHLWFQ SIFDMLEHFR VHPIPLESGG SSDVVLVSYV PSSQRQQGEQ SRSAGEEVPV
     HPRSENRPPP MTHPSPLNPL HGQIPHSLGQ KRRRGRQKWR QQQPQQPKRG KRKRKRAVEG
     SRKSWSPWLS WSPWLNWKRP
//