ID   H3BU51_HUMAN            Unreviewed;       184 AA.
AC   H3BU51;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   16-JAN-2019, entry version 42.
DE   SubName: Full=Neuroplastin {ECO:0000313|Ensembl:ENSP00000457470};
GN   Name=NPTN {ECO:0000313|Ensembl:ENSP00000457470};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000457470, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000457470, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16572171; DOI=10.1038/nature04601;
RA   Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA   Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA   Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA   Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA   DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R.,
RA   Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G.,
RA   Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A.,
RA   Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W.,
RA   Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X.,
RA   Sneddon K.M., Stewart S., Sougnez C., Stone S.M., Topham K.,
RA   Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S.,
RA   Nusbaum C.;
RT   "Analysis of the DNA sequence and duplication history of human
RT   chromosome 15.";
RL   Nature 440:671-675(2006).
RN   [2] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0000313|Ensembl:ENSP00000457470}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
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DR   EMBL; AC022735; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H3BU51; -.
DR   SMR; H3BU51; -.
DR   jPOST; H3BU51; -.
DR   MaxQB; H3BU51; -.
DR   PeptideAtlas; H3BU51; -.
DR   PRIDE; H3BU51; -.
DR   Ensembl; ENST00000565325; ENSP00000457470; ENSG00000156642.
DR   UCSC; uc059lea.1; human.
DR   EuPathDB; HostDB:ENSG00000156642.16; -.
DR   HGNC; HGNC:17867; NPTN.
DR   OpenTargets; ENSG00000156642; -.
DR   eggNOG; ENOG410IJET; Eukaryota.
DR   eggNOG; ENOG4111V1Q; LUCA.
DR   GeneTree; ENSGT00940000156195; -.
DR   ChiTaRS; NPTN; human.
DR   Proteomes; UP000005640; Chromosome 15.
DR   Bgee; ENSG00000156642; Expressed in 240 organ(s), highest expression level in caudate nucleus.
DR   ExpressionAtlas; H3BU51; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR027112; Neuroplastin.
DR   PANTHER; PTHR10075:SF5; PTHR10075:SF5; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00408; IGc2; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|EPD:H3BU51,
KW   ECO:0000213|MaxQB:H3BU51, ECO:0000213|PeptideAtlas:H3BU51};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     28       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        29    184       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003580697.
FT   TRANSMEM    135    155       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       33    124       Ig-like. {ECO:0000259|PROSITE:PS50835}.
SQ   SEQUENCE   184 AA;  20140 MW;  A006D057F8151DC5 CRC64;
     MSGSSLPSAL ALSLLLVSGS LLPGPGAAQN AAPDITGHKR SENKNEGQDA TMYCKSVGYP
     HPDWIWRKKE NGMPMDIVNT SGRFFIINKE NYTELNIVNL QITEDPGEYE CNATNAIGSA
     SVVTVLRVRS HLAPLWPFLG ILAEIIILVV IIVVYEKRKR PDEVPDDDEP AGPMKTNSTN
     NHKD
//