ID   H3BTW8_HUMAN            Unreviewed;       129 AA.
AC   H3BTW8;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   05-DEC-2018, entry version 43.
DE   SubName: Full=Serine/threonine-protein kinase/endoribonuclease IRE2 {ECO:0000313|Ensembl:ENSP00000457361};
GN   Name=ERN2 {ECO:0000313|Ensembl:ENSP00000457361};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000457361, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000457361, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15616553; DOI=10.1038/nature03187;
RA   Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X.,
RA   Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A.,
RA   Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.,
RA   Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L.,
RA   Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A.,
RA   Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D.,
RA   Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J.,
RA   Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA   Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I.,
RA   Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W.,
RA   Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A.,
RA   Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S.,
RA   Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA   Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA   Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L.,
RA   Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A.,
RA   Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L.,
RA   Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N.,
RA   Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M.,
RA   Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L.,
RA   Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D.,
RA   Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P.,
RA   Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M.,
RA   Rubin E.M., Pennacchio L.A.;
RT   "The sequence and analysis of duplication-rich human chromosome 16.";
RL   Nature 432:988-994(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000457361}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
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DR   EMBL; AC008870; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC012317; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KC877598; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KC877599; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H3BTW8; -.
DR   PeptideAtlas; H3BTW8; -.
DR   PRIDE; H3BTW8; -.
DR   Ensembl; ENST00000562562; ENSP00000457361; ENSG00000134398.
DR   UCSC; uc059sea.1; human.
DR   EuPathDB; HostDB:ENSG00000134398.13; -.
DR   HGNC; HGNC:16942; ERN2.
DR   OpenTargets; ENSG00000134398; -.
DR   eggNOG; KOG1027; Eukaryota.
DR   eggNOG; COG0515; LUCA.
DR   GeneTree; ENSGT00940000160812; -.
DR   ChiTaRS; ERN2; human.
DR   Proteomes; UP000005640; Chromosome 16.
DR   Bgee; ENSG00000134398; Expressed in 210 organ(s), highest expression level in nasal cavity epithelium.
DR   ExpressionAtlas; H3BTW8; baseline and differential.
DR   InterPro; IPR033523; IRE2.
DR   InterPro; IPR018391; PQQ_beta_propeller_repeat.
DR   InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR   PANTHER; PTHR13954:SF15; PTHR13954:SF15; 1.
DR   SMART; SM00564; PQQ; 1.
DR   SUPFAM; SSF50998; SSF50998; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     34       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        35    129       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003580696.
SQ   SEQUENCE   129 AA;  14084 MW;  21A67B415BF50462 CRC64;
     MASAVRGSRP WPRLGLQLQF AALLLGTLSP QVHTLRPENL LLVSTLDGSL HALSKQTGDL
     KWTLRDDPVI EGPMYVTEMA FLSDPADGSL YILGTQKQQG LMAGVQWYDH KAHCSLELLA
     SSNPRTSVS
//