ID   H3BTI0_HUMAN            Unreviewed;       496 AA.
AC   H3BTI0;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   13-FEB-2019, entry version 52.
DE   SubName: Full=Cysteine-rich secretory protein LCCL domain-containing 2 {ECO:0000313|Ensembl:ENSP00000457183};
GN   Name=CRISPLD2 {ECO:0000313|Ensembl:ENSP00000457183};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000457183, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000457183, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15616553; DOI=10.1038/nature03187;
RA   Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X.,
RA   Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A.,
RA   Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.,
RA   Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L.,
RA   Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A.,
RA   Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D.,
RA   Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J.,
RA   Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA   Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I.,
RA   Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W.,
RA   Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A.,
RA   Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S.,
RA   Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA   Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA   Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L.,
RA   Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A.,
RA   Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L.,
RA   Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N.,
RA   Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M.,
RA   Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L.,
RA   Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D.,
RA   Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P.,
RA   Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M.,
RA   Rubin E.M., Pennacchio L.A.;
RT   "The sequence and analysis of duplication-rich human chromosome 16.";
RL   Nature 432:988-994(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000457183}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
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DR   EMBL; AC025280; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H3BTI0; -.
DR   jPOST; H3BTI0; -.
DR   PeptideAtlas; H3BTI0; -.
DR   PRIDE; H3BTI0; -.
DR   Ensembl; ENST00000567845; ENSP00000457183; ENSG00000103196.
DR   UCSC; uc059xxw.1; human.
DR   EuPathDB; HostDB:ENSG00000103196.11; -.
DR   HGNC; HGNC:25248; CRISPLD2.
DR   OpenTargets; ENSG00000103196; -.
DR   eggNOG; KOG3017; Eukaryota.
DR   eggNOG; COG2340; LUCA.
DR   GeneTree; ENSGT00940000157410; -.
DR   ChiTaRS; CRISPLD2; human.
DR   Proteomes; UP000005640; Chromosome 16.
DR   Bgee; ENSG00000103196; Expressed in 225 organ(s), highest expression level in tibia.
DR   ExpressionAtlas; H3BTI0; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   Gene3D; 2.170.130.20; -; 2.
DR   Gene3D; 3.40.33.10; -; 1.
DR   InterPro; IPR018244; Allrgn_V5/Tpx1_CS.
DR   InterPro; IPR014044; CAP_domain.
DR   InterPro; IPR035940; CAP_sf.
DR   InterPro; IPR001283; CRISP-related.
DR   InterPro; IPR004043; LCCL.
DR   InterPro; IPR036609; LCCL_sf.
DR   PANTHER; PTHR10334; PTHR10334; 2.
DR   Pfam; PF00188; CAP; 1.
DR   Pfam; PF03815; LCCL; 2.
DR   PRINTS; PR00837; V5TPXLIKE.
DR   SMART; SM00603; LCCL; 2.
DR   SMART; SM00198; SCP; 1.
DR   SUPFAM; SSF55797; SSF55797; 1.
DR   SUPFAM; SSF69848; SSF69848; 2.
DR   PROSITE; PS01010; CRISP_2; 1.
DR   PROSITE; PS50820; LCCL; 2.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:H3BTI0,
KW   ECO:0000213|PeptideAtlas:H3BTI0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20    496       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003580683.
FT   DOMAIN      283    378       LCCL. {ECO:0000259|PROSITE:PS50820}.
FT   DOMAIN      384    477       LCCL. {ECO:0000259|PROSITE:PS50820}.
SQ   SEQUENCE   496 AA;  55791 MW;  1F44DA617F398AAE CRC64;
     MSCVLGGVIP LGLLFLVCGS QGYLLPNVTL LEELLSKYQH NESHSRVRRA IPREDKEEIL
     MLHNKLRGQV QPQASNMEYM TWDDELEKSA AAWASQCIWE HGPTSLLVSI GQNLGAHWGR
     YRSPGFHVQS WYDEVKDYTY PYPSECNPWC PERCSGPMCT HYTQIVWATT NKIGCAVNTC
     RKMTVWGEVW ENAVYFVCNY SPKGNWIGEA PYKNGRPCSE CPPSYGGSCR NNLCYRETYT
     PKPETDEMNE VETAPIPEEN HVWLQPRVMR PTKPKKTSAV NYMTQVVRCD TKMKDRCKGS
     TCNRYQCPAG CLNHKAKIFG TLFYESSSSI CRAAIHYGIL DDKGGLVDIT RNGKVPFFVK
     SERHGVQSLS KYKPSSSFMV SKVKVQDLDC YTTVAQLCPF EKPATHCPRI HCPAHCKDEP
     SYWAPVFGTN IYADTSSICK TAVHAGVISN ESGGDVDVMP VDKKKTYVGS LRNGVQSESL
     GTPRDGKAFR IFAVRQ
//