ID   TEX46_HUMAN             Reviewed;         121 AA.
AC   H3BTG2; H3BR39;
DT   18-SEP-2013, integrated into UniProtKB/Swiss-Prot.
DT   18-APR-2012, sequence version 1.
DT   16-JAN-2019, entry version 39.
DE   RecName: Full=Testis-expressed protein 46;
DE   Flags: Precursor;
GN   Name=TEX46 {ECO:0000312|HGNC:HGNC:44651}; Synonyms=C1orf234;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Placenta;
RA   Li W.B., Gruber C., Jessee J., Polayes D.;
RT   "Full-length cDNA libraries and normalization.";
RL   Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA   Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
RA   Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA   McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA   Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA   Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA   Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA   Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA   Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA   Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
RA   Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
RA   Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
RA   Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
RA   Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA   Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA   Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
RA   Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
RA   Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
RA   Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
RA   Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
RA   Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
RA   Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA   Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=H3BTG2-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=H3BTG2-2; Sequence=VSP_047833, VSP_047834;
CC   -!- TISSUE SPECIFICITY: Testis-specific. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BX377446; Type=Frameshift; Positions=11; Evidence={ECO:0000305};
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; BX377446; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; AL031428; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL355534; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AI652913; -; NOT_ANNOTATED_CDS; mRNA.
DR   CCDS; CCDS57978.1; -. [H3BTG2-1]
DR   RefSeq; NP_001229450.1; NM_001242521.1. [H3BTG2-1]
DR   UniGene; Hs.236896; -.
DR   ProteinModelPortal; H3BTG2; -.
DR   BioMuta; TEX46; -.
DR   PRIDE; H3BTG2; -.
DR   ProteomicsDB; 42630; -.
DR   Ensembl; ENST00000566855; ENSP00000457161; ENSG00000227868. [H3BTG2-1]
DR   GeneID; 729059; -.
DR   KEGG; hsa:729059; -.
DR   UCSC; uc001bgh.1; human. [H3BTG2-1]
DR   CTD; 729059; -.
DR   EuPathDB; HostDB:ENSG00000227868.5; -.
DR   GeneCards; TEX46; -.
DR   HGNC; HGNC:44651; TEX46.
DR   neXtProt; NX_H3BTG2; -.
DR   OpenTargets; ENSG00000227868; -.
DR   GeneTree; ENSGT00390000007769; -.
DR   OrthoDB; 1553813at2759; -.
DR   TreeFam; TF339051; -.
DR   ChiTaRS; C1orf234; human.
DR   GenomeRNAi; 729059; -.
DR   PRO; PR:H3BTG2; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   Bgee; ENSG00000227868; Expressed in 77 organ(s), highest expression level in right testis.
DR   ExpressionAtlas; H3BTG2; baseline and differential.
DR   Genevisible; H3BTG2; HS.
DR   InterPro; IPR038788; TEX46-like.
DR   PANTHER; PTHR39412; PTHR39412; 2.
DR   Pfam; PF17671; DUF5531; 2.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Complete proteome; Reference proteome; Signal.
FT   SIGNAL        1     38       {ECO:0000255}.
FT   CHAIN        39    121       Testis-expressed protein 46.
FT                                /FTId=PRO_0000423414.
FT   VAR_SEQ       1     20       Missing (in isoform 2).
FT                                {ECO:0000303|PubMed:15489334}.
FT                                /FTId=VSP_047833.
FT   VAR_SEQ      54     54       Q -> QQEEEKPKTSENDSKNSKAVNTKEVNRTHACFAL
FT                                (in isoform 2).
FT                                {ECO:0000303|PubMed:15489334}.
FT                                /FTId=VSP_047834.
SQ   SEQUENCE   121 AA;  14053 MW;  8693956F10C5DBD6 CRC64;
     MSLHGILASA GTIGAVAAWL MSYKPALFGF LFLLLLLSNW LVKYEHKLTL PEPQQDEILQ
     RLLFSEMKMK VLENQMFIIW NKMNHHGRSS RHRNFPMKKH RMRRHESICP TLSDCTSSSP
     S
//