ID   H3BSV1_HUMAN            Unreviewed;       203 AA.
AC   H3BSV1;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 8.
DT   16-JAN-2019, entry version 49.
DE   SubName: Full=Integrin alpha-L {ECO:0000313|Ensembl:ENSP00000456888};
DE   Flags: Fragment;
GN   Name=ITGAL {ECO:0000313|Ensembl:ENSP00000456888};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000456888, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000456888, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15616553; DOI=10.1038/nature03187;
RA   Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X.,
RA   Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A.,
RA   Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.,
RA   Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L.,
RA   Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A.,
RA   Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D.,
RA   Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J.,
RA   Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA   Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I.,
RA   Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W.,
RA   Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A.,
RA   Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S.,
RA   Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA   Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA   Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L.,
RA   Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A.,
RA   Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L.,
RA   Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N.,
RA   Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M.,
RA   Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L.,
RA   Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D.,
RA   Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P.,
RA   Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M.,
RA   Rubin E.M., Pennacchio L.A.;
RT   "The sequence and analysis of duplication-rich human chromosome 16.";
RL   Nature 432:988-994(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000456888}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
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DR   EMBL; AC002310; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC116348; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H3BSV1; -.
DR   jPOST; H3BSV1; -.
DR   PeptideAtlas; H3BSV1; -.
DR   PRIDE; H3BSV1; -.
DR   Ensembl; ENST00000564118; ENSP00000456888; ENSG00000005844.
DR   UCSC; uc059tet.1; human.
DR   EuPathDB; HostDB:ENSG00000005844.17; -.
DR   HGNC; HGNC:6148; ITGAL.
DR   OpenTargets; ENSG00000005844; -.
DR   eggNOG; KOG3637; Eukaryota.
DR   eggNOG; ENOG410XPVZ; LUCA.
DR   GeneTree; ENSGT00940000161495; -.
DR   ChiTaRS; ITGAL; human.
DR   Proteomes; UP000005640; Chromosome 16.
DR   Bgee; ENSG00000005844; Expressed in 210 organ(s), highest expression level in leukocyte.
DR   ExpressionAtlas; H3BSV1; baseline and differential.
DR   Gene3D; 2.130.10.130; -; 1.
DR   InterPro; IPR013519; Int_alpha_beta-p.
DR   InterPro; IPR028994; Integrin_alpha_N.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   Pfam; PF00092; VWA; 1.
DR   SUPFAM; SSF53300; SSF53300; 1.
DR   PROSITE; PS51470; FG_GAP; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:H3BSV1,
KW   ECO:0000213|MaxQB:H3BSV1, ECO:0000213|PeptideAtlas:H3BSV1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26    203       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5008415153.
FT   REPEAT       31     82       FG-GAP. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00803}.
FT   DOMAIN      110    203       VWFA. {ECO:0000259|PROSITE:PS50234}.
FT   NON_TER     203    203       {ECO:0000313|Ensembl:ENSP00000456888}.
SQ   SEQUENCE   203 AA;  21942 MW;  5F23594A2D027002 CRC64;
     MKDSCITVMA MALLSGFFFF APASSYNLDV RGARSFSPPR AGRHFGYRVL QVGNGVIVGA
     PGEGNSTGSL YQCQSGTGHC LPVTLRGSNY TSKYLGMTLA TDPTDGSILF AAVQFSTSYK
     TEFDFSDYVK RKDPDALLKH VKHMLLLTNT FGAINYVATE VFREELGARP DATKVLIIIT
     DGEATDSGNI DAAKDIIRYI IGV
//