ID   H3BSR6_HUMAN            Unreviewed;       403 AA.
AC   H3BSR6;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   16-JAN-2019, entry version 43.
DE   SubName: Full=Fractalkine {ECO:0000313|Ensembl:ENSP00000456830};
GN   Name=CX3CL1 {ECO:0000313|Ensembl:ENSP00000456830};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000456830, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000456830, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15616553; DOI=10.1038/nature03187;
RA   Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X.,
RA   Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A.,
RA   Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.,
RA   Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L.,
RA   Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A.,
RA   Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D.,
RA   Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J.,
RA   Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA   Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I.,
RA   Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W.,
RA   Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A.,
RA   Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S.,
RA   Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA   Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA   Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L.,
RA   Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A.,
RA   Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L.,
RA   Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N.,
RA   Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M.,
RA   Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L.,
RA   Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D.,
RA   Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P.,
RA   Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M.,
RA   Rubin E.M., Pennacchio L.A.;
RT   "The sequence and analysis of duplication-rich human chromosome 16.";
RL   Nature 432:988-994(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000456830}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
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DR   EMBL; AC009052; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H3BSR6; -.
DR   SMR; H3BSR6; -.
DR   PeptideAtlas; H3BSR6; -.
DR   PRIDE; H3BSR6; -.
DR   Ensembl; ENST00000563383; ENSP00000456830; ENSG00000006210.
DR   UCSC; uc059urj.1; human.
DR   EuPathDB; HostDB:ENSG00000006210.6; -.
DR   HGNC; HGNC:10647; CX3CL1.
DR   OpenTargets; ENSG00000006210; -.
DR   eggNOG; ENOG410IJQZ; Eukaryota.
DR   eggNOG; ENOG41116BY; LUCA.
DR   GeneTree; ENSGT00940000153084; -.
DR   OMA; YQSLQGC; -.
DR   Proteomes; UP000005640; Chromosome 16.
DR   Bgee; ENSG00000006210; Expressed in 200 organ(s), highest expression level in thoracic mammary gland.
DR   ExpressionAtlas; H3BSR6; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008009; F:chemokine activity; IEA:InterPro.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0050902; P:leukocyte adhesive activation; IEA:InterPro.
DR   CDD; cd00274; Chemokine_CX3C; 1.
DR   InterPro; IPR039809; Chemokine_b/g/d.
DR   InterPro; IPR034127; Chemokine_CX3C.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   InterPro; IPR008097; CX3CL1.
DR   InterPro; IPR036048; Interleukin_8-like_sf.
DR   PANTHER; PTHR12015; PTHR12015; 1.
DR   PANTHER; PTHR12015:SF92; PTHR12015:SF92; 1.
DR   Pfam; PF00048; IL8; 1.
DR   SMART; SM00199; SCY; 1.
DR   SUPFAM; SSF54117; SSF54117; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|MaxQB:H3BSR6,
KW   ECO:0000213|PeptideAtlas:H3BSR6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     24       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        25    403       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003581498.
FT   TRANSMEM    348    368       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       35     95       SCY. {ECO:0000259|SMART:SM00199}.
SQ   SEQUENCE   403 AA;  42762 MW;  4D95CB1F6F2949A4 CRC64;
     MAPISLSWLL RLATFCHLTV LLAGTSLNSG QHHGVTKCNI TCSKMTSKIP VALLIHYQQN
     QASCGKRAII LETRQHRLFC ADPKEQWVKD AMQHLDRQAA ALTRNGGTFE KQIGEVKPRT
     TPAAGGMDES VVLEPEATGE SSSLEPTPSS QEAQRALGTS PELPTGVTGS SGTRLPPTPK
     AQDGGPVGTE LFRVPPVSTA ATWQSSAPHQ PGPSLWAEAK TSEAPSTQDP STQASTASSP
     APEENAPSEG QRVWGQGQSP RPENSLEREE MGPVPAHTDA FQDWGPGSMA HVSVVPVSSE
     GTPSREPVAS GSWTPKAEEP IHATMDPQRL GVLITPVPDA QAATRRQAVG LLAFLGLLFC
     LGVAMFTYQS LQGCPRKMAG EMAEGLRYIP RSCGSNSYVL VPV
//