ID   H3BSG2_HUMAN            Unreviewed;       749 AA.
AC   H3BSG2;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   05-DEC-2018, entry version 51.
DE   SubName: Full=Cadherin-16 {ECO:0000313|Ensembl:ENSP00000456690};
GN   Name=CDH16 {ECO:0000313|Ensembl:ENSP00000456690};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000456690, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000456690, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15616553; DOI=10.1038/nature03187;
RA   Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X.,
RA   Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A.,
RA   Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.,
RA   Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L.,
RA   Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A.,
RA   Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D.,
RA   Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J.,
RA   Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA   Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I.,
RA   Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W.,
RA   Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A.,
RA   Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S.,
RA   Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA   Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA   Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L.,
RA   Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A.,
RA   Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L.,
RA   Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N.,
RA   Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M.,
RA   Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L.,
RA   Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D.,
RA   Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P.,
RA   Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M.,
RA   Rubin E.M., Pennacchio L.A.;
RT   "The sequence and analysis of duplication-rich human chromosome 16.";
RL   Nature 432:988-994(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000456690}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
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DR   EMBL; AC009084; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H3BSG2; -.
DR   PeptideAtlas; H3BSG2; -.
DR   PRIDE; H3BSG2; -.
DR   Ensembl; ENST00000570262; ENSP00000456690; ENSG00000166589.
DR   UCSC; uc059vlw.1; human.
DR   EuPathDB; HostDB:ENSG00000166589.12; -.
DR   HGNC; HGNC:1755; CDH16.
DR   OpenTargets; ENSG00000166589; -.
DR   eggNOG; KOG3594; Eukaryota.
DR   eggNOG; ENOG410XQHI; LUCA.
DR   GeneTree; ENSGT00940000161650; -.
DR   Proteomes; UP000005640; Chromosome 16.
DR   Bgee; ENSG00000166589; Expressed in 57 organ(s), highest expression level in adult mammalian kidney.
DR   ExpressionAtlas; H3BSG2; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0016339; P:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; IEA:InterPro.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   InterPro; IPR030721; Cadherin-16.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR020894; Cadherin_CS.
DR   PANTHER; PTHR24028:SF1; PTHR24028:SF1; 1.
DR   Pfam; PF00028; Cadherin; 4.
DR   PRINTS; PR00205; CADHERIN.
DR   SMART; SM00112; CA; 5.
DR   SUPFAM; SSF49313; SSF49313; 5.
DR   PROSITE; PS00232; CADHERIN_1; 1.
PE   1: Evidence at protein level;
KW   Calcium {ECO:0000256|SAAS:SAAS00020193};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAAS:SAAS00616217, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|EPD:H3BSG2,
KW   ECO:0000213|MaxQB:H3BSG2, ECO:0000213|PeptideAtlas:H3BSG2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00436611};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00616217,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00616217,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19    749       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003581493.
FT   TRANSMEM    704    725       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       68    161       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      174    254       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      278    367       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      392    482       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      503    580       CA. {ECO:0000259|SMART:SM00112}.
SQ   SEQUENCE   749 AA;  81308 MW;  C064FB86D91ACF27 CRC64;
     MVPAWLWLLC VSVPQVTLEM QDGHVLWGPQ PVLVHVKDEN DQVPHFSQAI YRARLSRGTR
     PGIPFLFLEA SDRDEPGTAN SDLRFHILSQ APAQPSPDMF QLEPRLGALA LSPKGSTSLD
     HALERTYQLL VQVKDMGDQA SGHQATATVE VSIIESTWVS LEPIHLAENL KVLYPHHMAQ
     VHWSGGDVHY HLESHPPGPF EVNAEGNLYV TRELDREAQA EYLLQVRAQN SHGEDYAAPL
     ELHVLVMDEN DNVPICPPRD PTVSIPELSP PGTEVTRLSA EDADAPGSPN SHVVYQLLSP
     EPEDGVEGRA FQVDPTSGSV TLGVLPLRAG QNILLLVLAM DLAGAEGGFS STCEVEVAVT
     DINDHAPEFI TSQIGPISLP EDVEPGTLVA MLTAIDADLE PAFRLMDFAI ERGDTEGTFG
     LDWEPDSGHV RLRLCKNLSY EAAPSHEVVV VVQSVAKLVG PGPGPGATAT VTVLVERVMP
     PPKLDQESYE ASVPISAPAG SFLLTIQPSD PISRTLRFSL VNDSEGWLCI EKFSGEVHTA
     QSLQGAQPGD TYTVLVEAQD TDEPRLSASA PLVIHFLKAP PAPALTLAPV PSQYLCTPRQ
     DHGLIVSGPS KDPDLASGHG PYSFTLGPNP TVQRDWRLQT LNGSHAYLTL ALHWVEPREH
     IIPVVVSHNA QMWQLLVRVI VCRCNVEGQC MRKVGRMKGM PTKLSAVGIL VGTLVAIGIF
     LILIFTHWTM SRKKDPDQPA DSVPLKATV
//