ID   T178B_HUMAN             Reviewed;         294 AA.
AC   H3BS89;
DT   03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT   18-APR-2012, sequence version 1.
DT   16-JAN-2019, entry version 46.
DE   RecName: Full=Transmembrane protein 178B;
DE   Flags: Precursor;
GN   Name=TMEM178B;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA   Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA   Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA   Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA   Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA   Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA   Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA   Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA   Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA   Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA   Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA   Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA   Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA   Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA   Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA   Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA   Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA   Waterston R.H., Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-142.
RC   TISSUE=Brain;
RA   Ebert L., Heil O., Hennig S., Neubert P., Partsch E., Peters M.,
RA   Radelof U., Schneider D., Korn B.;
RL   Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TMEM178 family. {ECO:0000305}.
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DR   EMBL; AC004928; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC005692; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC006362; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC006396; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC073878; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BX114205; -; NOT_ANNOTATED_CDS; mRNA.
DR   CCDS; CCDS59086.1; -.
DR   RefSeq; NP_001182207.1; NM_001195278.1.
DR   UniGene; Hs.283851; -.
DR   ProteinModelPortal; H3BS89; -.
DR   IntAct; H3BS89; 2.
DR   iPTMnet; H3BS89; -.
DR   PhosphoSitePlus; H3BS89; -.
DR   BioMuta; TMEM178B; -.
DR   PaxDb; H3BS89; -.
DR   PRIDE; H3BS89; -.
DR   ProteomicsDB; 42288; -.
DR   Ensembl; ENST00000565468; ENSP00000456594; ENSG00000261115.
DR   GeneID; 100507421; -.
DR   KEGG; hsa:100507421; -.
DR   UCSC; uc003vwg.3; human.
DR   CTD; 100507421; -.
DR   EuPathDB; HostDB:ENSG00000261115.5; -.
DR   GeneCards; TMEM178B; -.
DR   HGNC; HGNC:44112; TMEM178B.
DR   HPA; HPA048771; -.
DR   neXtProt; NX_H3BS89; -.
DR   OpenTargets; ENSG00000261115; -.
DR   eggNOG; ENOG410IEXN; Eukaryota.
DR   eggNOG; ENOG410YC3G; LUCA.
DR   GeneTree; ENSGT00390000015299; -.
DR   InParanoid; H3BS89; -.
DR   OMA; WHSLHLR; -.
DR   OrthoDB; 1336222at2759; -.
DR   ChiTaRS; TMEM178B; human.
DR   PRO; PR:H3BS89; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   Bgee; ENSG00000261115; Expressed in 159 organ(s), highest expression level in cardiac muscle of right atrium.
DR   ExpressionAtlas; H3BS89; baseline and differential.
DR   Genevisible; H3BS89; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR   InterPro; IPR039625; T178A/B.
DR   PANTHER; PTHR32005; PTHR32005; 1.
DR   Pfam; PF13903; Claudin_2; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Glycoprotein; Membrane; Reference proteome; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL        1     23       {ECO:0000255}.
FT   CHAIN        24    294       Transmembrane protein 178B.
FT                                /FTId=PRO_0000419261.
FT   TRANSMEM    172    192       Helical. {ECO:0000255}.
FT   TRANSMEM    206    226       Helical. {ECO:0000255}.
FT   TRANSMEM    252    272       Helical. {ECO:0000255}.
FT   CARBOHYD    148    148       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    152    152       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
SQ   SEQUENCE   294 AA;  33409 MW;  D13DE2CDF3F949C4 CRC64;
     MAAGRLLLYT GLSLALCALG MLAVAICSDH WYETDARKHR DRCKAFNTRR VDPGFIYNNN
     NNLPLRASRS RLDRWEGKLL RARNRRQLFA MSPADECSRQ YNSTNMGLWR KCHRQGFDPE
     IAALIRKGEI ERCTYIKYHY SSATIPRNLT FNITKTIRQD EWHALHLRRM TAGFMGMAVA
     IILFGWIIGV LGCCWDRGLM QYVAGLLFLM GGTFCIISLC TCVAGINFEL SRYPRYLYGL
     PDDISHGYGW SMFCAWGGLG LTLISGFFCT LAPSVQPVPR TNYPKSRPEN GTVC
//