ID   H3BRW5_HUMAN            Unreviewed;       140 AA.
AC   H3BRW5;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   13-FEB-2019, entry version 64.
DE   RecName: Full=Succinate dehydrogenase [ubiquinone] cytochrome b small subunit {ECO:0000256|RuleBase:RU364031};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000456434, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000456434, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0000313|Ensembl:ENSP00000456434}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Membrane-anchoring subunit of succinate dehydrogenase
CC       (SDH) that is involved in complex II of the mitochondrial electron
CC       transport chain and is responsible for transferring electrons from
CC       succinate to ubiquinone (coenzyme Q).
CC       {ECO:0000256|RuleBase:RU364031}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000256|RuleBase:RU364031}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU364031}.
CC   -!- SIMILARITY: Belongs to the CybS family.
CC       {ECO:0000256|RuleBase:RU364031}.
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DR   EMBL; AP002007; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP002884; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF455507; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF455511; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF511119; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   SMR; H3BRW5; -.
DR   STRING; 9606.ENSP00000456434; -.
DR   jPOST; H3BRW5; -.
DR   MaxQB; H3BRW5; -.
DR   PRIDE; H3BRW5; -.
DR   Ensembl; ENST00000531744; ENSP00000456957; ENSG00000255292.
DR   Ensembl; ENST00000532699; ENSP00000456434; ENSG00000255292.
DR   UCSC; uc058hht.1; human.
DR   EuPathDB; HostDB:ENSG00000255292.6; -.
DR   GeneCards; ENSG00000255292; -.
DR   eggNOG; KOG4097; Eukaryota.
DR   eggNOG; ENOG4111RTW; LUCA.
DR   GeneTree; ENSGT00390000010003; -.
DR   OMA; CTAKIHA; -.
DR   TreeFam; TF313310; -.
DR   ChiTaRS; SDHD; human.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000255292; Expressed in 80 organ(s), highest expression level in heart.
DR   GO; GO:0016021; C:integral component of membrane; IEA:InterPro.
DR   GO; GO:0005749; C:mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone); IBA:GO_Central.
DR   GO; GO:0020037; F:heme binding; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0048039; F:ubiquinone binding; IBA:GO_Central.
DR   GO; GO:0006121; P:mitochondrial electron transport, succinate to ubiquinone; IBA:GO_Central.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IBA:GO_Central.
DR   Gene3D; 1.20.1300.10; -; 1.
DR   InterPro; IPR007992; CybS.
DR   InterPro; IPR034804; SQR/QFR_C/D.
DR   PANTHER; PTHR13337; PTHR13337; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Electron transport {ECO:0000256|RuleBase:RU364031};
KW   Heme {ECO:0000256|RuleBase:RU364031};
KW   Iron {ECO:0000256|RuleBase:RU364031};
KW   Membrane {ECO:0000256|RuleBase:RU364031};
KW   Metal-binding {ECO:0000256|RuleBase:RU364031};
KW   Mitochondrion {ECO:0000256|RuleBase:RU364031};
KW   Mitochondrion inner membrane {ECO:0000256|RuleBase:RU364031};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transit peptide {ECO:0000256|RuleBase:RU364031};
KW   Transport {ECO:0000256|RuleBase:RU364031};
KW   Tricarboxylic acid cycle {ECO:0000256|RuleBase:RU364031}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19    140       Succinate dehydrogenase [ubiquinone]
FT                                cytochrome b small subunit.
FT                                {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5015093550.
SQ   SEQUENCE   140 AA;  15501 MW;  142E644771DEBEFA CRC64;
     MAVLWRLSAV CGALGGRALL LRTPVVRPAH ISAFLQDRPI PEWCGVQHIH LSPSHHSGSK
     AASLHWTSER VVSVLLLGLL PAAYLNPCSA MDYSLAAALT LHGHCLQCQI VHSCPLLENQ
     IHLSLKFPDY FIKMKPWRKI
//