ID   H3BRN4_HUMAN            Unreviewed;       515 AA.
AC   H3BRN4;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   16-JAN-2019, entry version 47.
DE   SubName: Full=4-aminobutyrate aminotransferase, mitochondrial {ECO:0000313|Ensembl:ENSP00000456330};
GN   Name=ABAT {ECO:0000313|Ensembl:ENSP00000456330};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000456330, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000456330, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15616553; DOI=10.1038/nature03187;
RA   Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X.,
RA   Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A.,
RA   Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.,
RA   Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L.,
RA   Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A.,
RA   Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D.,
RA   Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J.,
RA   Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA   Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I.,
RA   Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W.,
RA   Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A.,
RA   Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S.,
RA   Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA   Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA   Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L.,
RA   Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A.,
RA   Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L.,
RA   Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N.,
RA   Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M.,
RA   Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L.,
RA   Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D.,
RA   Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P.,
RA   Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M.,
RA   Rubin E.M., Pennacchio L.A.;
RT   "The sequence and analysis of duplication-rich human chromosome 16.";
RL   Nature 432:988-994(2004).
RN   [2] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0000313|Ensembl:ENSP00000456330}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
RN   [4] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
CC   -!- SIMILARITY: Belongs to the class-III pyridoxal-phosphate-dependent
CC       aminotransferase family. {ECO:0000256|RuleBase:RU003560}.
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DR   EMBL; AC007224; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC012173; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H3BRN4; -.
DR   SMR; H3BRN4; -.
DR   jPOST; H3BRN4; -.
DR   MaxQB; H3BRN4; -.
DR   PRIDE; H3BRN4; -.
DR   Ensembl; ENST00000567812; ENSP00000456330; ENSG00000183044.
DR   UCSC; uc059qow.1; human.
DR   EuPathDB; HostDB:ENSG00000183044.11; -.
DR   HGNC; HGNC:23; ABAT.
DR   OpenTargets; ENSG00000183044; -.
DR   eggNOG; KOG1405; Eukaryota.
DR   eggNOG; COG0160; LUCA.
DR   GeneTree; ENSGT00550000074885; -.
DR   OMA; IQTGGCG; -.
DR   ChiTaRS; ABAT; human.
DR   Proteomes; UP000005640; Chromosome 16.
DR   Bgee; ENSG00000183044; Expressed in 228 organ(s), highest expression level in substantia nigra.
DR   ExpressionAtlas; H3BRN4; baseline and differential.
DR   GO; GO:0005739; C:mitochondrion; IDA:HPA.
DR   GO; GO:0003867; F:4-aminobutyrate transaminase activity; IEA:InterPro.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0009448; P:gamma-aminobutyric acid metabolic process; IEA:InterPro.
DR   CDD; cd00610; OAT_like; 1.
DR   Gene3D; 3.40.640.10; -; 1.
DR   Gene3D; 3.90.1150.10; -; 1.
DR   InterPro; IPR004631; 4NH2But_aminotransferase_euk.
DR   InterPro; IPR005814; Aminotrans_3.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_dom1.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   Pfam; PF00202; Aminotran_3; 1.
DR   PIRSF; PIRSF000521; Transaminase_4ab_Lys_Orn; 1.
DR   SUPFAM; SSF53383; SSF53383; 1.
DR   TIGRFAMs; TIGR00699; GABAtrns_euk; 1.
DR   PROSITE; PS00600; AA_TRANSFER_CLASS_3; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:H3BRN4,
KW   ECO:0000213|MaxQB:H3BRN4, ECO:0000213|PeptideAtlas:H3BRN4};
KW   Pyridoxal phosphate {ECO:0000256|RuleBase:RU003560};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     17       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        18    515       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003580270.
SQ   SEQUENCE   515 AA;  58141 MW;  C5EE9D7D9271F219 CRC64;
     MWWQHAKGVP VPQGVMASML LAQRLACSFQ HSYRLLVPGS RHISQAAAKV DVEFDYDGPL
     MKTEVPGPRS QELMKQLNII QNAEAVHFFC NYEESRGNYL VDVDGNRMLD LYSQISSVPI
     GYSHPALLKL IQQPQNASMF VNRPALGILP PENFVEKLRQ SLLSVAPKGM SQLITMACGS
     CSNENALKTI FMWYRSKERG QRGFSQEELE TCMINQAPGC PDYSILSFMG AFHGRTMGCL
     ATTHSKAIHK IDIPSFDWPI APFPRLKYPL EEFVKENQQE EARCLEEVED LIVKYRKKKK
     TVAGIIVEPI QSEGGDNHAS DDFFRKLRDI ARKHGCAFLV DEVQTGGGCT GKFWAHEHWG
     LDDPADVMTF SKKMMTGGFF HKEEFRPNAP YRIFNTWLGD PSKNLLLAEV INIIKREDLL
     NNAAHAGKAL LTGLLDLQAR YPQFISRVRG RGTFCSFDTP DDSIRNKLIL IARNKGVVLG
     GCGDKSIRFR PTLVFRDHHA HLFLNIFSDI LADFK
//