ID   H3BQ04_HUMAN            Unreviewed;       143 AA.
AC   H3BQ04;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   16-JAN-2019, entry version 36.
DE   SubName: Full=Beta-hexosaminidase subunit alpha {ECO:0000313|Ensembl:ENSP00000455545};
GN   Name=HEXA {ECO:0000313|Ensembl:ENSP00000455545};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000455545, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000455545, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16572171; DOI=10.1038/nature04601;
RA   Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA   Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA   Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA   Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA   DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R.,
RA   Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G.,
RA   Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A.,
RA   Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W.,
RA   Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X.,
RA   Sneddon K.M., Stewart S., Sougnez C., Stone S.M., Topham K.,
RA   Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S.,
RA   Nusbaum C.;
RT   "Analysis of the DNA sequence and duplication history of human
RT   chromosome 15.";
RL   Nature 440:671-675(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000455545}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
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DR   EMBL; AC009690; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF456090; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H3BQ04; -.
DR   jPOST; H3BQ04; -.
DR   PeptideAtlas; H3BQ04; -.
DR   PRIDE; H3BQ04; -.
DR   Ensembl; ENST00000567411; ENSP00000455545; ENSG00000213614.
DR   UCSC; uc059lbh.1; human.
DR   EuPathDB; HostDB:ENSG00000213614.9; -.
DR   HGNC; HGNC:4878; HEXA.
DR   OpenTargets; ENSG00000213614; -.
DR   eggNOG; KOG2499; Eukaryota.
DR   eggNOG; COG3525; LUCA.
DR   GeneTree; ENSGT00390000008107; -.
DR   ChiTaRS; HEXA; human.
DR   Proteomes; UP000005640; Chromosome 15.
DR   Bgee; ENSG00000213614; Expressed in 225 organ(s), highest expression level in tendon of biceps brachii.
DR   ExpressionAtlas; H3BQ04; baseline and differential.
DR   Gene3D; 3.30.379.10; -; 1.
DR   InterPro; IPR029018; Hex-like_dom2.
DR   InterPro; IPR029019; HEX_eukaryotic_N.
DR   Pfam; PF14845; Glycohydro_20b2; 1.
DR   SUPFAM; SSF55545; SSF55545; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23    143       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003581461.
FT   DOMAIN       23    139       Glycohydro_20b2.
FT                                {ECO:0000259|Pfam:PF14845}.
SQ   SEQUENCE   143 AA;  16274 MW;  5450EA473996F0FC CRC64;
     MTSSRLWFSL LLAAAFAGRA TALWPWPQNF QTSDQRYVLY PNNFQFQYDV SSAAQPGCSV
     LDEAFQRYRD LLFGSGSWPR PYLTGKRHTL EKNVLVVSVV TPGCNQLPTL ESVENYTLTI
     NDDQCLLLSE TVWGALRVLY QQD
//