ID   H3BPU8_HUMAN            Unreviewed;       254 AA.
AC   H3BPU8;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   05-DEC-2018, entry version 50.
DE   SubName: Full=Deoxyribonuclease-1-like 2 {ECO:0000313|Ensembl:ENSP00000455478};
DE   Flags: Fragment;
GN   Name=DNASE1L2 {ECO:0000313|Ensembl:ENSP00000455478};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000455478, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000455478, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15616553; DOI=10.1038/nature03187;
RA   Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X.,
RA   Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A.,
RA   Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.,
RA   Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L.,
RA   Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A.,
RA   Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D.,
RA   Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J.,
RA   Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA   Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I.,
RA   Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W.,
RA   Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A.,
RA   Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S.,
RA   Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA   Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA   Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L.,
RA   Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A.,
RA   Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L.,
RA   Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N.,
RA   Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M.,
RA   Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L.,
RA   Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D.,
RA   Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P.,
RA   Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M.,
RA   Rubin E.M., Pennacchio L.A.;
RT   "The sequence and analysis of duplication-rich human chromosome 16.";
RL   Nature 432:988-994(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000455478}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
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DR   EMBL; AC009065; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H3BPU8; -.
DR   SMR; H3BPU8; -.
DR   PeptideAtlas; H3BPU8; -.
DR   PRIDE; H3BPU8; -.
DR   Ensembl; ENST00000569184; ENSP00000455478; ENSG00000167968.
DR   UCSC; uc059pkk.1; human.
DR   EuPathDB; HostDB:ENSG00000167968.12; -.
DR   HGNC; HGNC:2958; DNASE1L2.
DR   OpenTargets; ENSG00000167968; -.
DR   GeneTree; ENSGT00940000153734; -.
DR   ChiTaRS; DNASE1L2; human.
DR   Proteomes; UP000005640; Chromosome 16.
DR   Bgee; ENSG00000167968; Expressed in 93 organ(s), highest expression level in skin of leg.
DR   ExpressionAtlas; H3BPU8; baseline and differential.
DR   GO; GO:0004536; F:deoxyribonuclease activity; IEA:InterPro.
DR   GO; GO:0006308; P:DNA catabolic process; IEA:InterPro.
DR   Gene3D; 3.60.10.10; -; 1.
DR   InterPro; IPR018057; Deoxyribonuclease-1_AS.
DR   InterPro; IPR016202; DNase_I.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   PIRSF; PIRSF000988; DNase_I_euk; 3.
DR   PRINTS; PR00130; DNASEI.
DR   SMART; SM00476; DNaseIc; 1.
DR   SUPFAM; SSF56219; SSF56219; 1.
DR   PROSITE; PS00919; DNASE_I_1; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:H3BPU8,
KW   ECO:0000213|PeptideAtlas:H3BPU8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19    254       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003580626.
FT   ACT_SITE     96     96       {ECO:0000256|PIRSR:PIRSR000988-1}.
FT   ACT_SITE    167    167       {ECO:0000256|PIRSR:PIRSR000988-1}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSP00000455478}.
FT   NON_TER     254    254       {ECO:0000313|Ensembl:ENSP00000455478}.
SQ   SEQUENCE   254 AA;  27856 MW;  8954FE0668675A5C CRC64;
     PRALLAALWA LEAAGTAALR IGAFNIQSFG DSKVSDPACG SIIAKILAGY DLALVQEVRD
     PDLSAVSALM EQINSVSEHE YSFVSSQPLG RDQYKEMYLF VYRKDAVSVV DTYLYPDPED
     VFSREPFVVK FSAPGTGERA PPLPSRRALT PPPLPAAAQN LVLIPLHAAP HQAVAEIDAL
     YDVYLDVIDK WGTDDWAAIR LRSSEVFKWL IPDSADTTVG NSDCAYDRIV ACGARLRRSL
     KPQSATVHDF QEEF
//