ID   H3BPB7_HUMAN            Unreviewed;        54 AA.
AC   H3BPB7;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 2.
DT   13-FEB-2019, entry version 36.
DE   SubName: Full=Interleukin-34 {ECO:0000313|Ensembl:ENSP00000455240};
DE   Flags: Fragment;
GN   Name=IL34 {ECO:0000313|Ensembl:ENSP00000455240};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000455240, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000455240, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15616553; DOI=10.1038/nature03187;
RA   Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X.,
RA   Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A.,
RA   Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.,
RA   Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L.,
RA   Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A.,
RA   Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D.,
RA   Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J.,
RA   Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA   Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I.,
RA   Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W.,
RA   Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A.,
RA   Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S.,
RA   Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA   Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA   Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L.,
RA   Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A.,
RA   Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L.,
RA   Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N.,
RA   Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M.,
RA   Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L.,
RA   Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D.,
RA   Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P.,
RA   Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M.,
RA   Rubin E.M., Pennacchio L.A.;
RT   "The sequence and analysis of duplication-rich human chromosome 16.";
RL   Nature 432:988-994(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000455240}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AC020763; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC106804; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H3BPB7; -.
DR   PRIDE; H3BPB7; -.
DR   Ensembl; ENST00000563721; ENSP00000455240; ENSG00000157368.
DR   UCSC; uc059wrc.1; human.
DR   EuPathDB; HostDB:ENSG00000157368.10; -.
DR   HGNC; HGNC:28529; IL34.
DR   OpenTargets; ENSG00000157368; -.
DR   eggNOG; ENOG410IX9Y; Eukaryota.
DR   eggNOG; ENOG410Z6RS; LUCA.
DR   GeneTree; ENSGT00390000000932; -.
DR   ChiTaRS; IL34; human.
DR   Proteomes; UP000005640; Chromosome 16.
DR   Bgee; ENSG00000157368; Expressed in 192 organ(s), highest expression level in islet of Langerhans.
DR   ExpressionAtlas; H3BPB7; baseline and differential.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0005157; F:macrophage colony-stimulating factor receptor binding; IEA:InterPro.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:InterPro.
DR   GO; GO:0001934; P:positive regulation of protein phosphorylation; IEA:InterPro.
DR   Gene3D; 1.20.1250.80; -; 1.
DR   InterPro; IPR020415; IL-34.
DR   InterPro; IPR038328; IL-34_sf.
DR   PANTHER; PTHR28606; PTHR28606; 1.
DR   Pfam; PF15036; IL34; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21     54       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003580619.
FT   NON_TER      54     54       {ECO:0000313|Ensembl:ENSP00000455240}.
SQ   SEQUENCE   54 AA;  6441 MW;  33115815383DA669 CRC64;
     MPRGFTWLRY LGIFLGVALG NEPLEMWPLT QNEECTVTGF LRDKLQYRSR LQYM
//