ID   H3BPB3_HUMAN            Unreviewed;       128 AA.
AC   H3BPB3;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   16-JAN-2019, entry version 52.
DE   SubName: Full=Protein disulfide-isomerase TMX3 {ECO:0000313|Ensembl:ENSP00000455234};
GN   Name=TMX3 {ECO:0000313|Ensembl:ENSP00000455234};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000455234, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000455234, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16177791; DOI=10.1038/nature03983;
RA   Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D.,
RA   Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S.,
RA   Bloom T., Bugalter B., Butler J., Cook A., DeCaprio D., Engels R.,
RA   Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T.,
RA   Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E.,
RA   Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H.,
RA   O'Leary S.B., O'Neill K., Piqani B., Smith C.L., Talamas J.A.,
RA   Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q.,
RA   Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y.,
RA   Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 18.";
RL   Nature 437:551-555(2005).
RN   [2] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0000313|Ensembl:ENSP00000455234}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AC040896; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H3BPB3; -.
DR   SMR; H3BPB3; -.
DR   jPOST; H3BPB3; -.
DR   MaxQB; H3BPB3; -.
DR   PeptideAtlas; H3BPB3; -.
DR   PRIDE; H3BPB3; -.
DR   Ensembl; ENST00000565918; ENSP00000455234; ENSG00000166479.
DR   UCSC; uc060pyc.1; human.
DR   EuPathDB; HostDB:ENSG00000166479.9; -.
DR   HGNC; HGNC:24718; TMX3.
DR   OpenTargets; ENSG00000166479; -.
DR   eggNOG; KOG4277; Eukaryota.
DR   eggNOG; COG0526; LUCA.
DR   GeneTree; ENSGT00930000151022; -.
DR   ChiTaRS; TMX3; human.
DR   Proteomes; UP000005640; Chromosome 18.
DR   Bgee; ENSG00000166479; Expressed in 206 organ(s), highest expression level in frontal cortex.
DR   ExpressionAtlas; H3BPB3; baseline and differential.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0045454; P:cell redox homeostasis; IEA:InterPro.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   InterPro; IPR017937; Thioredoxin_CS.
DR   InterPro; IPR013766; Thioredoxin_domain.
DR   Pfam; PF00085; Thioredoxin; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   PROSITE; PS00194; THIOREDOXIN_1; 1.
DR   PROSITE; PS51352; THIOREDOXIN_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:H3BPB3,
KW   ECO:0000213|MaxQB:H3BPB3, ECO:0000213|PeptideAtlas:H3BPB3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     26       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        27    128       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003581506.
FT   DOMAIN       10    128       Thioredoxin.
FT                                {ECO:0000259|PROSITE:PS51352}.
SQ   SEQUENCE   128 AA;  14364 MW;  1206F7BD1ACC3B60 CRC64;
     MAAWKSWTAL RLCATVVVLD MVVCKGFVED LDESFKENRN DDIWLVDFYA PWCGHCKKLE
     PIWNEVGLEM KSIGSPVKVG KMDATSYSSI ASEFGVRGYP TIKLRFPGGL KIGVWPFFIG
     EIKRGLGI
//