ID H3BN02_HUMAN Unreviewed; 1169 AA. AC H3BN02; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 13-FEB-2019, entry version 60. DE SubName: Full=Integrin alpha-X {ECO:0000313|Ensembl:ENSP00000454623}; GN Name=ITGAX {ECO:0000313|Ensembl:ENSP00000454623}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000454623, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000454623, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15616553; DOI=10.1038/nature03187; RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., RA Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., RA Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., RA Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., RA Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., RA Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., RA Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., RA Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., RA Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., RA Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., RA Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., RA Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., RA Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., RA Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., RA Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., RA Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., RA Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., RA Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., RA Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., RA Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., RA Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., RA Rubin E.M., Pennacchio L.A.; RT "The sequence and analysis of duplication-rich human chromosome 16."; RL Nature 432:988-994(2004). RN [2] {ECO:0000313|Ensembl:ENSP00000454623} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SUBUNIT: Heterodimer of an alpha and a beta subunit. CC {ECO:0000256|SAAS:SAAS01130326}. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003762}; CC Single-pass type I membrane protein CC {ECO:0000256|RuleBase:RU003762}. CC -!- SIMILARITY: Belongs to the integrin alpha chain family. CC {ECO:0000256|RuleBase:RU003762, ECO:0000256|SAAS:SAAS00534092}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC093520; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; NP_001273304.1; NM_001286375.1. DR UniGene; Hs.248472; -. DR ProteinModelPortal; H3BN02; -. DR jPOST; H3BN02; -. DR PRIDE; H3BN02; -. DR Ensembl; ENST00000562522; ENSP00000454623; ENSG00000140678. DR GeneID; 3687; -. DR UCSC; uc002ebt.5; human. DR CTD; 3687; -. DR EuPathDB; HostDB:ENSG00000140678.16; -. DR HGNC; HGNC:6152; ITGAX. DR OpenTargets; ENSG00000140678; -. DR eggNOG; ENOG410IPBA; Eukaryota. DR eggNOG; ENOG410ZFBE; LUCA. DR GeneTree; ENSGT00940000154838; -. DR OMA; QNPSIQC; -. DR OrthoDB; 73876at2759; -. DR ChiTaRS; ITGAX; human. DR GenomeRNAi; 3687; -. DR Proteomes; UP000005640; Chromosome 16. DR Bgee; ENSG00000140678; Expressed in 119 organ(s), highest expression level in blood. DR ExpressionAtlas; H3BN02; baseline and differential. DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl. DR GO; GO:0008305; C:integrin complex; IEA:InterPro. DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW. DR GO; GO:0051607; P:defense response to virus; IEA:Ensembl. DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW. DR Gene3D; 2.130.10.130; -; 1. DR Gene3D; 3.40.50.410; -; 1. DR InterPro; IPR013517; FG-GAP. DR InterPro; IPR013519; Int_alpha_beta-p. DR InterPro; IPR000413; Integrin_alpha. DR InterPro; IPR013649; Integrin_alpha-2. DR InterPro; IPR018184; Integrin_alpha_C_CS. DR InterPro; IPR028994; Integrin_alpha_N. DR InterPro; IPR032695; Integrin_dom_sf. DR InterPro; IPR002035; VWF_A. DR InterPro; IPR036465; vWFA_dom_sf. DR Pfam; PF01839; FG-GAP; 2. DR Pfam; PF00357; Integrin_alpha; 1. DR Pfam; PF08441; Integrin_alpha2; 1. DR Pfam; PF00092; VWA; 1. DR PRINTS; PR01185; INTEGRINA. DR SMART; SM00191; Int_alpha; 5. DR SMART; SM00327; VWA; 1. DR SUPFAM; SSF53300; SSF53300; 1. DR SUPFAM; SSF69179; SSF69179; 3. DR PROSITE; PS51470; FG_GAP; 7. DR PROSITE; PS00242; INTEGRIN_ALPHA; 1. DR PROSITE; PS50234; VWFA; 1. PE 1: Evidence at protein level; KW Cell adhesion {ECO:0000256|RuleBase:RU003762, KW ECO:0000256|SAAS:SAAS01101218}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Integrin {ECO:0000256|RuleBase:RU003762, KW ECO:0000256|SAAS:SAAS00494682}; KW Membrane {ECO:0000256|RuleBase:RU003762, KW ECO:0000256|SAAS:SAAS00494657}; KW Proteomics identification {ECO:0000213|MaxQB:H3BN02, KW ECO:0000213|PeptideAtlas:H3BN02}; KW Receptor {ECO:0000256|RuleBase:RU003762, KW ECO:0000256|SAAS:SAAS01101220}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Repeat {ECO:0000256|SAAS:SAAS00504086}; KW Signal {ECO:0000256|RuleBase:RU003762}; KW Transmembrane {ECO:0000256|RuleBase:RU003762, KW ECO:0000256|SAAS:SAAS00494657}; KW Transmembrane helix {ECO:0000256|RuleBase:RU003762, KW ECO:0000256|SAAS:SAAS00494657}. FT SIGNAL 1 19 {ECO:0000256|RuleBase:RU003762}. FT CHAIN 20 1169 {ECO:0000256|RuleBase:RU003762}. FT /FTId=PRO_5001424941. FT TRANSMEM 1108 1128 Helical. {ECO:0000256|RuleBase:RU003762}. FT REPEAT 23 78 FG-GAP. {ECO:0000256|PROSITE- FT ProRule:PRU00803}. FT REPEAT 79 138 FG-GAP. {ECO:0000256|PROSITE- FT ProRule:PRU00803}. FT DOMAIN 151 329 VWFA. {ECO:0000259|PROSITE:PS50234}. FT REPEAT 340 391 FG-GAP. {ECO:0000256|PROSITE- FT ProRule:PRU00803}. FT REPEAT 392 443 FG-GAP. {ECO:0000256|PROSITE- FT ProRule:PRU00803}. FT REPEAT 444 504 FG-GAP. {ECO:0000256|PROSITE- FT ProRule:PRU00803}. FT REPEAT 507 565 FG-GAP. {ECO:0000256|PROSITE- FT ProRule:PRU00803}. FT REPEAT 570 630 FG-GAP. {ECO:0000256|PROSITE- FT ProRule:PRU00803}. SQ SEQUENCE 1169 AA; 128537 MW; 0E4C64E082AADB8B CRC64; MTRTRAALLL FTALATSLGF NLDTEELTAF RVDSAGFGDS VVQYANSWVV VGAPQKITAA NQTGGLYQCG YSTGACEPIG LQVPPEAVNM SLGLSLASTT SPSQLLACGP TVHHECGRNM YLTGLCFLLG PTQLTQRLPV SRQECPRQEQ DIVFLIDGSG SISSRNFATM MNFVRAVISQ FQRPSTQFSL MQFSNKFQTH FTFEEFRRSS NPLSLLASVH QLQGFTYTAT AIQNVVHRLF HASYGARRDA AKILIVITDG KKEGDSLDYK DVIPMADAAG IIRYAIGVGL AFQNRNSWKE LNDIASKPSQ EHIFKVEDFD ALKDIQNQLK EKIFAIEGTE TTSSSSFELE MAQEGFSAVF TPDGPVLGAV GSFTWSGGAF LYPPNMSPTF INMSQENVDM RDSYLGYSTE LALWKGVQSL VLGAPRYQHT GKAVIFTQVS RQWRMKAEVT GTQIGSYFGA SLCSVDVDSD GSTDLVLIGA PHYYEQTRGG QVSVCPLPRG WRRWWCDAVL YGEQGHPWGR FGAALTVLGD VNGDKLTDVV IGAPGEEENR GAVYLFHGVL GPSISPSHSQ RIAGSQLSSR LQYFGQALSG GQDLTQDGLV DLAVGARGQV LLLRTRPVLW VGVSMQFIPA EIPRSAFECR EQVVSEQTLV QSNICLYIDK RSKNLLGSRD LQSSVTLDLA LDPGRLSPRA TFQETKNRSL SRVRVLGLKA HCENFNLLLP SCVEDSVTPI TLRLNFTLVG KPLLAFRNLR PMLAADAQRY FTASLPFEKN CGADHICQDN LGISFSFPGL KSLLVGSNLE LNAEVMVWND GEDSYGTTIT FSHPAGLSYR YVAEGQKQGQ LRSLHLTCDS APVGSQGTWS TSCRINHLIF RGGAQITFLA TFDVSPKAVL GDRLLLTANV SSENNTPRTS KTTFQLELPV KYAVYTVVSS HEQFTKYLNF SESEEKESHV AMHRYQVNNL GQRDLPVSIN FWVPVELNQE AVWMDVEVSH PQNPSLRCSS EKIAPPASDF LAHIQKNPVL DCSIAGCLRF RCDVPSFSVQ EELDFTLKGN LSFGWVRQIL QKKVSVVSVA EITFDTSVYS QLPGQEAFMR AQTTTVLEKY KVHNPTPLIV GSSIGGLLLL ALITAVLYKV GFFKRQYKEM MEEANGQIAP ENGTQTPSPP TPHYPQDNV //