ID   H3BMN4_HUMAN            Unreviewed;       218 AA.
AC   H3BMN4;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 2.
DT   16-JAN-2019, entry version 35.
DE   RecName: Full=Battenin {ECO:0000256|RuleBase:RU361113};
DE   Flags: Fragment;
GN   Name=CLN3 {ECO:0000313|Ensembl:ENSP00000454466};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000454466, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000454466, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15616553; DOI=10.1038/nature03187;
RA   Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X.,
RA   Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A.,
RA   Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.,
RA   Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L.,
RA   Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A.,
RA   Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D.,
RA   Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J.,
RA   Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA   Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I.,
RA   Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W.,
RA   Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A.,
RA   Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S.,
RA   Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA   Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA   Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L.,
RA   Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A.,
RA   Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L.,
RA   Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N.,
RA   Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M.,
RA   Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L.,
RA   Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D.,
RA   Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P.,
RA   Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M.,
RA   Rubin E.M., Pennacchio L.A.;
RT   "The sequence and analysis of duplication-rich human chromosome 16.";
RL   Nature 432:988-994(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000454466}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane
CC       {ECO:0000256|RuleBase:RU361113}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361113}.
CC   -!- SIMILARITY: Belongs to the battenin family.
CC       {ECO:0000256|RuleBase:RU361113}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361113}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AC138894; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   jPOST; H3BMN4; -.
DR   PeptideAtlas; H3BMN4; -.
DR   PRIDE; H3BMN4; -.
DR   Ensembl; ENST00000564091; ENSP00000454466; ENSG00000188603.
DR   UCSC; uc059smk.1; human.
DR   EuPathDB; HostDB:ENSG00000188603.16; -.
DR   HGNC; HGNC:2074; CLN3.
DR   OpenTargets; ENSG00000188603; -.
DR   eggNOG; KOG3880; Eukaryota.
DR   eggNOG; ENOG410XT4Z; LUCA.
DR   GeneTree; ENSGT00390000003249; -.
DR   ChiTaRS; CLN3; human.
DR   Proteomes; UP000005640; Chromosome 16.
DR   Bgee; ENSG00000188603; Expressed in 89 organ(s), highest expression level in mucosa of transverse colon.
DR   ExpressionAtlas; H3BMN4; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR003492; Battenin_disease_Cln3.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   PANTHER; PTHR10981; PTHR10981; 1.
DR   Pfam; PF02487; CLN3; 1.
DR   PRINTS; PR01315; BATTENIN.
DR   SUPFAM; SSF103473; SSF103473; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|RuleBase:RU361113};
KW   Proteomics identification {ECO:0000213|MaxQB:H3BMN4,
KW   ECO:0000213|PeptideAtlas:H3BMN4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|RuleBase:RU361113};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361113}.
FT   SIGNAL        1     16       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        17    218       Battenin. {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5008415141.
FT   TRANSMEM     61     78       Helical. {ECO:0000256|RuleBase:RU361113}.
FT   TRANSMEM    124    145       Helical. {ECO:0000256|RuleBase:RU361113}.
FT   TRANSMEM    151    170       Helical. {ECO:0000256|RuleBase:RU361113}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSP00000454466}.
SQ   SEQUENCE   218 AA;  24629 MW;  879A941129563537 CRC64;
     ALLLASYFLL LTSPEAQDPG GEEEAESAAR QPLIRTEAPE SKPGSSSSLS LRERWTVFKG
     LLWYIVPLVV VYFAEYFINQ GLFELLFFWN TSLSHAQQYR WYQMLYQAGV FASRSSLRCC
     RIRFTWALAL LQCLNLVFLL ADVWFGFLPS IYLVFLIILY EGLLGGAAYV NTFHNIALET
     SDEHREFAMA ATCISDTLGI SLSGLLALPL HDFLCQLS
//