ID   H3BM21_HUMAN            Unreviewed;       787 AA.
AC   H3BM21;
DT   26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 1.
DT   13-FEB-2019, entry version 42.
DE   RecName: Full=Integrin beta {ECO:0000256|RuleBase:RU000633};
DE   Flags: Fragment;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000456711, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000456711, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000456711}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU000633};
CC       Single-pass type I membrane protein
CC       {ECO:0000256|RuleBase:RU000633}.
CC   -!- SIMILARITY: Belongs to the integrin beta chain family.
CC       {ECO:0000256|RuleBase:RU000633}.
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DR   EMBL; AC068234; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H3BM21; -.
DR   BioMuta; ENSG00000259753; -.
DR   jPOST; H3BM21; -.
DR   PeptideAtlas; H3BM21; -.
DR   PRIDE; H3BM21; -.
DR   Ensembl; ENST00000560629; ENSP00000456711; ENSG00000259753.
DR   UCSC; uc060gnn.1; human.
DR   EuPathDB; HostDB:ENSG00000259753.1; -.
DR   GeneCards; ENSG00000259753; -.
DR   eggNOG; KOG1226; Eukaryota.
DR   eggNOG; ENOG410XP60; LUCA.
DR   GeneTree; ENSGT00940000153526; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000259753; Expressed in 33 organ(s), highest expression level in descending thoracic aorta.
DR   GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR   GO; GO:0005925; C:focal adhesion; IBA:GO_Central.
DR   GO; GO:0008305; C:integrin complex; IBA:GO_Central.
DR   GO; GO:0001968; F:fibronectin binding; IBA:GO_Central.
DR   GO; GO:0005178; F:integrin binding; IBA:GO_Central.
DR   GO; GO:0033627; P:cell adhesion mediated by integrin; IBA:GO_Central.
DR   GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR   GO; GO:0007160; P:cell-matrix adhesion; IBA:GO_Central.
DR   GO; GO:0007229; P:integrin-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0070527; P:platelet aggregation; IEA:InterPro.
DR   Gene3D; 3.40.50.410; -; 1.
DR   InterPro; IPR013111; EGF_extracell.
DR   InterPro; IPR040622; I-EGF_1.
DR   InterPro; IPR027068; Integrin_beta-3.
DR   InterPro; IPR033760; Integrin_beta_N.
DR   InterPro; IPR015812; Integrin_bsu.
DR   InterPro; IPR014836; Integrin_bsu_cyt_dom.
DR   InterPro; IPR012896; Integrin_bsu_tail.
DR   InterPro; IPR036349; Integrin_bsu_tail_dom_sf.
DR   InterPro; IPR002369; Integrin_bsu_VWA.
DR   InterPro; IPR032695; Integrin_dom_sf.
DR   InterPro; IPR016201; PSI.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR10082; PTHR10082; 1.
DR   PANTHER; PTHR10082:SF25; PTHR10082:SF25; 1.
DR   Pfam; PF07974; EGF_2; 1.
DR   Pfam; PF18372; I-EGF_1; 1.
DR   Pfam; PF08725; Integrin_b_cyt; 1.
DR   Pfam; PF07965; Integrin_B_tail; 1.
DR   Pfam; PF00362; Integrin_beta; 1.
DR   Pfam; PF17205; PSI_integrin; 1.
DR   PIRSF; PIRSF002512; Integrin_B; 1.
DR   PRINTS; PR01186; INTEGRINB.
DR   SMART; SM00187; INB; 1.
DR   SMART; SM01241; Integrin_b_cyt; 1.
DR   SMART; SM01242; Integrin_B_tail; 1.
DR   SMART; SM00423; PSI; 1.
DR   SUPFAM; SSF53300; SSF53300; 1.
DR   SUPFAM; SSF69179; SSF69179; 1.
DR   SUPFAM; SSF69687; SSF69687; 1.
DR   PROSITE; PS00243; INTEGRIN_BETA; 1.
PE   3: Inferred from homology;
KW   Cell adhesion {ECO:0000256|RuleBase:RU000633};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR002512-1};
KW   Integrin {ECO:0000256|RuleBase:RU000633,
KW   ECO:0000256|SAAS:SAAS00895071};
KW   Membrane {ECO:0000256|SAAS:SAAS00895947, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00895947,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00895947,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     15       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        16    787       Integrin beta. {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5012723086.
FT   TRANSMEM    708    730       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       19     65       PSI. {ECO:0000259|SMART:SM00423}.
FT   DOMAIN       27    450       INB. {ECO:0000259|SMART:SM00187}.
FT   DOMAIN      623    707       Integrin_B_tail.
FT                                {ECO:0000259|SMART:SM01242}.
FT   DOMAIN      731    765       Integrin_b_cyt.
FT                                {ECO:0000259|SMART:SM01241}.
FT   DISULFID     28     38       {ECO:0000256|PIRSR:PIRSR002512-1}.
FT   DISULFID     31     64       {ECO:0000256|PIRSR:PIRSR002512-1}.
FT   DISULFID     41     53       {ECO:0000256|PIRSR:PIRSR002512-1}.
FT   DISULFID    192    199       {ECO:0000256|PIRSR:PIRSR002512-1}.
FT   DISULFID    247    288       {ECO:0000256|PIRSR:PIRSR002512-1}.
FT   DISULFID    389    401       {ECO:0000256|PIRSR:PIRSR002512-1}.
FT   DISULFID    421    670       {ECO:0000256|PIRSR:PIRSR002512-1}.
FT   DISULFID    448    452       {ECO:0000256|PIRSR:PIRSR002512-1}.
FT   DISULFID    463    475       {ECO:0000256|PIRSR:PIRSR002512-1}.
FT   DISULFID    472    510       {ECO:0000256|PIRSR:PIRSR002512-1}.
FT   DISULFID    477    486       {ECO:0000256|PIRSR:PIRSR002512-1}.
FT   DISULFID    488    501       {ECO:0000256|PIRSR:PIRSR002512-1}.
FT   DISULFID    516    521       {ECO:0000256|PIRSR:PIRSR002512-1}.
FT   DISULFID    518    551       {ECO:0000256|PIRSR:PIRSR002512-1}.
FT   DISULFID    523    536       {ECO:0000256|PIRSR:PIRSR002512-1}.
FT   DISULFID    538    543       {ECO:0000256|PIRSR:PIRSR002512-1}.
FT   DISULFID    557    562       {ECO:0000256|PIRSR:PIRSR002512-1}.
FT   DISULFID    559    590       {ECO:0000256|PIRSR:PIRSR002512-1}.
FT   DISULFID    564    573       {ECO:0000256|PIRSR:PIRSR002512-1}.
FT   DISULFID    575    582       {ECO:0000256|PIRSR:PIRSR002512-1}.
FT   DISULFID    596    601       {ECO:0000256|PIRSR:PIRSR002512-1}.
FT   DISULFID    598    646       {ECO:0000256|PIRSR:PIRSR002512-1}.
FT   DISULFID    603    613       {ECO:0000256|PIRSR:PIRSR002512-1}.
FT   DISULFID    616    619       {ECO:0000256|PIRSR:PIRSR002512-1}.
FT   DISULFID    623    632       {ECO:0000256|PIRSR:PIRSR002512-1}.
FT   DISULFID    629    702       {ECO:0000256|PIRSR:PIRSR002512-1}.
FT   DISULFID    650    678       {ECO:0000256|PIRSR:PIRSR002512-1}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSP00000456711}.
SQ   SEQUENCE   787 AA;  86981 MW;  4FC7B99667039F14 CRC64;
     XTVLALGALA GVGVGGPNIC TTRGVSSCQQ CLAVSPMCAW CSDEALPLGS PRCDLKENLL
     KDNCAPESIE FPVSEARVLE DRPLSDKGSG DSSQVTQVSP QRIALRLRPD DSKNFSIQVR
     QVEDYPVDIY YLMDLSYSMK DDLWSIQNLG TKLATQMRKL TSNLRIGFGA FVDKPVSPYM
     YISPPEALEN PCYDMKTTCL PMFGYKHVLT LTDQVTRFNE EVKKQSVSRN RDAPEGGFDA
     IMQATVCDEK IGWRNDASHL LVFTTDAKTH IALDGRLAGI VQPNDGQCHV GSDNHYSAST
     TMDYPSLGLM TEKLSQKNIN LIFAVTENVV NLYQNYSELI PGTTVGVLSM DSSNVLQLIV
     DAYGKIRSKV ELEVRDLPEE LSLSFNATCL NNEVIPGLKS CMGLKIGDTV SFSIEAKVRG
     CPQEKEKSFT IKPVGFKDSL IVQVTFDCDC ACQAQAEPNS HRCNNGNGTF ECGVCRCGPG
     WLGSQCECSE EDYRPSQQDE CSPREGQPVC SQRGECLCGQ CVCHSSDFGK ITGKYCECDD
     FSCVRYKGEM CSGHGQCSCG DCLCDSDWTG YYCNCTTRTD TCMSSNGLLC SGRGKCECGS
     CVCIQPGSYG DTCEKCPTCP DACTFKKECV ECKKFDRGAL HDENTCNRYC RDEIESVKEL
     KDTGKDAVNC TYKNEDDCVV RFQYYEDSSG KSILYVVEEP ECPKGPDILV VLLSVMGAIL
     LIGLAALLIW KLLITIHDRK EFAKFEEERA RAKWDTEILL YYCSFILVHQ SLESLRTEFT
     SKQKDGN
//