ID   H3BLT0_HUMAN            Unreviewed;       731 AA.
AC   H3BLT0;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   16-JAN-2019, entry version 45.
DE   SubName: Full=Receptor tyrosine-protein kinase erbB-4 {ECO:0000313|Ensembl:ENSP00000260943};
DE   Flags: Fragment;
GN   Name=ERBB4 {ECO:0000313|Ensembl:ENSP00000260943};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000260943, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000260943, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000260943}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
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DR   EMBL; AC012069; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC068970; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC092840; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC093823; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC096547; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC105921; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC108216; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC108220; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF456758; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H3BLT0; -.
DR   jPOST; H3BLT0; -.
DR   MaxQB; H3BLT0; -.
DR   PeptideAtlas; H3BLT0; -.
DR   PRIDE; H3BLT0; -.
DR   Ensembl; ENST00000260943; ENSP00000260943; ENSG00000178568.
DR   UCSC; uc061rzu.1; human.
DR   EuPathDB; HostDB:ENSG00000178568.13; -.
DR   HGNC; HGNC:3432; ERBB4.
DR   OpenTargets; ENSG00000178568; -.
DR   eggNOG; KOG1025; Eukaryota.
DR   eggNOG; ENOG410XNSR; LUCA.
DR   GeneTree; ENSGT00940000154695; -.
DR   ChiTaRS; ERBB4; human.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; ENSG00000178568; Expressed in 168 organ(s), highest expression level in oviduct epithelium.
DR   ExpressionAtlas; H3BLT0; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:InterPro.
DR   GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:InterPro.
DR   CDD; cd00064; FU; 3.
DR   Gene3D; 3.80.20.20; -; 2.
DR   InterPro; IPR006211; Furin-like_Cys-rich_dom.
DR   InterPro; IPR006212; Furin_repeat.
DR   InterPro; IPR032778; GF_recep_IV.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR000494; Rcpt_L-dom.
DR   InterPro; IPR036941; Rcpt_L-dom_sf.
DR   Pfam; PF00757; Furin-like; 1.
DR   Pfam; PF14843; GF_recep_IV; 1.
DR   Pfam; PF01030; Recep_L_domain; 2.
DR   SMART; SM00261; FU; 5.
DR   SUPFAM; SSF57184; SSF57184; 2.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|MaxQB:H3BLT0,
KW   ECO:0000213|PeptideAtlas:H3BLT0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26    731       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003581426.
FT   TRANSMEM    642    665       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       55    166       Recep_L_domain.
FT                                {ECO:0000259|Pfam:PF01030}.
FT   DOMAIN      186    334       Furin-like. {ECO:0000259|Pfam:PF00757}.
FT   DOMAIN      358    477       Recep_L_domain.
FT                                {ECO:0000259|Pfam:PF01030}.
FT   DOMAIN      502    633       GF_recep_IV. {ECO:0000259|Pfam:PF14843}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSP00000260943}.
FT   NON_TER     731    731       {ECO:0000313|Ensembl:ENSP00000260943}.
SQ   SEQUENCE   731 AA;  81011 MW;  2B7D1823697095E5 CRC64;
     XKPATGLWVW VSLLVAAGTV QPSDSQSVCA GTENKLSSLS DLEQQYRALR KYYENCEVVM
     GNLEITSIEH NRDLSFLRSV REVTGYVLVA LNQFRYLPLE NLRIIRGTKL YEDRYALAIF
     LNYRKDGNFG LQELGLKNLT EILNGGVYVD QNKFLCYADT IHWQDIVRNP WPSNLTLVST
     NGSSGCGRCH KSCTGRCWGP TENHCQTLTR TVCAEQCDGR CYGPYVSDCC HRECAGGCSG
     PKDTDCFACM NFNDSGACVT QCPQTFVYNP TTFQLEHNFN AKYTYGAFCV KKCPHNFVVD
     SSSCVRACPS SKMEVEENGI KMCKPCTDIC PKACDGIGTG SLMSAQTVDS SNIDKFINCT
     KINGNLIFLV TGIHGDPYNA IEAIDPEKLN VFRTVREITG FLNIQSWPPN MTDFSVFSNL
     VTIGGRVLYS GLSLLILKQQ GITSLQFQSL KEISAGNIYI TDNSNLCYYH TINWTTLFST
     INQRIVIRDN RKAENCTAEG MVCNHLCSSD GCWGPGPDQC LSCRRFSRGR ICIESCNLYD
     GEFREFENGS ICVECDPQCE KMEDGLLTCH GPGPDNCTKC SHFKDGPNCV EKCPDGLQGA
     NSFIFKYADP DRECHPCHPN CTQGCIGSSI EDCIGLMDRT PLIAAGVIGG LFILVIVGLT
     FAVYVRRKSI KKKRALRRFL ETELVEPLTP SGTAPNQAQL RILKETELKR VKVLGSGAFG
     TVYKGIWVPE G
//