ID   H0YNC5_HUMAN            Unreviewed;       148 AA.
AC   H0YNC5;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   16-JAN-2019, entry version 52.
DE   SubName: Full=Disintegrin and metalloproteinase domain-containing protein 10 {ECO:0000313|Ensembl:ENSP00000453952};
DE   Flags: Fragment;
GN   Name=ADAM10 {ECO:0000313|Ensembl:ENSP00000453952};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000453952, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000453952, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16572171; DOI=10.1038/nature04601;
RA   Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA   Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA   Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA   Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA   DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R.,
RA   Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G.,
RA   Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A.,
RA   Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W.,
RA   Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X.,
RA   Sneddon K.M., Stewart S., Sougnez C., Stone S.M., Topham K.,
RA   Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S.,
RA   Nusbaum C.;
RT   "Analysis of the DNA sequence and duplication history of human
RT   chromosome 15.";
RL   Nature 440:671-675(2006).
RN   [2] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0000313|Ensembl:ENSP00000453952}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
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DR   EMBL; AC018904; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC091046; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H0YNC5; -.
DR   jPOST; H0YNC5; -.
DR   MaxQB; H0YNC5; -.
DR   PeptideAtlas; H0YNC5; -.
DR   PRIDE; H0YNC5; -.
DR   Ensembl; ENST00000559053; ENSP00000453952; ENSG00000137845.
DR   UCSC; uc059jrw.1; human.
DR   EuPathDB; HostDB:ENSG00000137845.14; -.
DR   HGNC; HGNC:188; ADAM10.
DR   OpenTargets; ENSG00000137845; -.
DR   eggNOG; KOG3658; Eukaryota.
DR   eggNOG; ENOG410XQWB; LUCA.
DR   GeneTree; ENSGT00940000160579; -.
DR   ChiTaRS; ADAM10; human.
DR   Proteomes; UP000005640; Chromosome 15.
DR   Bgee; ENSG00000137845; Expressed in 242 organ(s), highest expression level in testis.
DR   ExpressionAtlas; H0YNC5; baseline and differential.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006509; P:membrane protein ectodomain proteolysis; IEA:InterPro.
DR   GO; GO:0007219; P:Notch signaling pathway; IEA:InterPro.
DR   Gene3D; 3.40.390.10; -; 1.
DR   InterPro; IPR027053; ADAM_10.
DR   InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR   InterPro; IPR001590; Peptidase_M12B.
DR   PANTHER; PTHR11905:SF4; PTHR11905:SF4; 1.
DR   PROSITE; PS50215; ADAM_MEPRO; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:H0YNC5,
KW   ECO:0000213|MaxQB:H0YNC5, ECO:0000213|PeptideAtlas:H0YNC5};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19    148       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003546075.
FT   DOMAIN       20    148       Peptidase M12B.
FT                                {ECO:0000259|PROSITE:PS50215}.
FT   NON_TER     148    148       {ECO:0000313|Ensembl:ENSP00000453952}.
SQ   SEQUENCE   148 AA;  15951 MW;  5EA6E5E413A6C516 CRC64;
     MVLLRVLILL LSWAAGMGDR DFDDGVLGLA WVGAPSGSSG GICEKSKLYS DGKKKSLNTG
     IITVQNYGSH VPPKVSHITF AHEVGHNFGS PHDSGTECTP GESKNLGQKE NGNYIMYARA
     TSGDKLNNNK FSLCSIRNIS QVLEKKRN
//