ID   H0YNA8_HUMAN            Unreviewed;       463 AA.
AC   H0YNA8;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   16-JAN-2019, entry version 45.
DE   SubName: Full=Homeobox protein Meis3 {ECO:0000313|Ensembl:ENSP00000453934};
GN   Name=MEIS3 {ECO:0000313|Ensembl:ENSP00000453934};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000453934, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000453934, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000453934}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-
CC       ProRule:PRU00108, ECO:0000256|SAAS:SAAS00863205}.
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DR   EMBL; AC073548; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_016882500.1; XM_017027011.1.
DR   UniGene; Hs.380923; -.
DR   ProteinModelPortal; H0YNA8; -.
DR   MaxQB; H0YNA8; -.
DR   PeptideAtlas; H0YNA8; -.
DR   PRIDE; H0YNA8; -.
DR   Ensembl; ENST00000561096; ENSP00000453934; ENSG00000105419.
DR   GeneID; 56917; -.
DR   UCSC; uc061alh.1; human.
DR   CTD; 56917; -.
DR   EuPathDB; HostDB:ENSG00000105419.17; -.
DR   HGNC; HGNC:29537; MEIS3.
DR   OpenTargets; ENSG00000105419; -.
DR   GeneTree; ENSGT00940000161057; -.
DR   OrthoDB; 1126341at2759; -.
DR   ChiTaRS; MEIS3; human.
DR   GenomeRNAi; 56917; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000105419; Expressed in 119 organ(s), highest expression level in myometrium.
DR   ExpressionAtlas; H0YNA8; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR008422; Homeobox_KN_domain.
DR   InterPro; IPR032453; PKNOX/Meis_N.
DR   Pfam; PF05920; Homeobox_KN; 1.
DR   Pfam; PF16493; Meis_PKNOX_N; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00108,
KW   ECO:0000256|SAAS:SAAS00863210};
KW   Homeobox {ECO:0000256|PROSITE-ProRule:PRU00108,
KW   ECO:0000256|SAAS:SAAS00863217};
KW   Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108,
KW   ECO:0000256|SAAS:SAAS00863219};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     31       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        32    463       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003546239.
FT   DOMAIN      348    411       Homeobox. {ECO:0000259|PROSITE:PS50071}.
FT   DNA_BIND    350    412       Homeobox. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00108}.
SQ   SEQUENCE   463 AA;  50275 MW;  5DB53697BA0380F9 CRC64;
     MCTLCTTMRG SYRRCPWISL SVCLSLCLCH CLLTPLSPSL FPPSQTLPSL PLGPPAHMSG
     ISAWTGSSLP TEAAPGDLEG FKLGGSDTWG PQYDELPHYP GIVDGPAALA SFPETVPAVP
     GPYGPHRPPQ PLPPGLDSDG LKREKDEIYG HPLFPLLALV FEKCELATCS PRDGAGAGLG
     TPPGGDVCSS DSFNEDIAAF AKQVRSERPL FSSNPELDNL MIQAIQVLRF HLLELEKVHD
     LCDNFCHRYI TCLKGKMPID LVIEDRDGGC REDFEDYPAS CPSLPDQNNM WIRDHEDSGS
     VHLGTPGPSS GGLASQSGDN SSDQGDGLDT SVASPSSGGE DEDLDQERRR NKKRGIFPKV
     ATNIMRAWLF QHLSHPYPSE EQKKQLAQDT GLTILQVNNW FINARRRIVQ PMIDQSNRTG
     QGAAFSPEGQ PIGGYTETQP HVAVRPPGSV GMSLNLEGEW HYL
//