ID   H0YN85_HUMAN            Unreviewed;       136 AA.
AC   H0YN85;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   16-JAN-2019, entry version 44.
DE   SubName: Full=CD276 antigen {ECO:0000313|Ensembl:ENSP00000453907};
DE   Flags: Fragment;
GN   Name=CD276 {ECO:0000313|Ensembl:ENSP00000453907};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000453907, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000453907, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16572171; DOI=10.1038/nature04601;
RA   Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA   Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA   Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA   Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA   DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R.,
RA   Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G.,
RA   Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A.,
RA   Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W.,
RA   Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X.,
RA   Sneddon K.M., Stewart S., Sougnez C., Stone S.M., Topham K.,
RA   Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S.,
RA   Nusbaum C.;
RT   "Analysis of the DNA sequence and duplication history of human
RT   chromosome 15.";
RL   Nature 440:671-675(2006).
RN   [2] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0000313|Ensembl:ENSP00000453907}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
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DR   EMBL; AC022188; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC100838; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H0YN85; -.
DR   jPOST; H0YN85; -.
DR   MaxQB; H0YN85; -.
DR   PeptideAtlas; H0YN85; -.
DR   PRIDE; H0YN85; -.
DR   Ensembl; ENST00000558689; ENSP00000453907; ENSG00000103855.
DR   UCSC; uc059lei.1; human.
DR   EuPathDB; HostDB:ENSG00000103855.17; -.
DR   HGNC; HGNC:19137; CD276.
DR   OpenTargets; ENSG00000103855; -.
DR   eggNOG; ENOG410IR2H; Eukaryota.
DR   eggNOG; ENOG410ZB69; LUCA.
DR   GeneTree; ENSGT00940000154641; -.
DR   ChiTaRS; CD276; human.
DR   Proteomes; UP000005640; Chromosome 15.
DR   Bgee; ENSG00000103855; Expressed in 188 organ(s), highest expression level in layer of synovial tissue.
DR   ExpressionAtlas; H0YN85; baseline and differential.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013106; Ig_V-set.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00406; IGv; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:H0YN85,
KW   ECO:0000213|MaxQB:H0YN85, ECO:0000213|PeptideAtlas:H0YN85};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     28       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        29    136       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003546762.
FT   DOMAIN       43    136       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   NON_TER     136    136       {ECO:0000313|Ensembl:ENSP00000453907}.
SQ   SEQUENCE   136 AA;  14456 MW;  06CFAF07E342F560 CRC64;
     MLRRRGSPGM GVHVGAALGA LWFCLTGALE VQVPEDPVVA LVGTDATLCC SFSPEPGFSL
     AQLNLIWQLT DTKQLVHSFA EGQDQGSAYA NRTALFPDLL AQGNASLRLQ RVRVADEGSF
     TCFVSIRDFG SAAVSL
//