ID   H0YMX3_HUMAN            Unreviewed;       326 AA.
AC   H0YMX3;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   05-DEC-2018, entry version 42.
DE   SubName: Full=Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 {ECO:0000313|Ensembl:ENSP00000453780};
DE   Flags: Fragment;
GN   Name=LINGO1 {ECO:0000313|Ensembl:ENSP00000453780};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000453780, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000453780, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16572171; DOI=10.1038/nature04601;
RA   Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA   Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA   Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA   Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA   DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R.,
RA   Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G.,
RA   Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A.,
RA   Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W.,
RA   Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X.,
RA   Sneddon K.M., Stewart S., Sougnez C., Stone S.M., Topham K.,
RA   Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S.,
RA   Nusbaum C.;
RT   "Analysis of the DNA sequence and duplication history of human
RT   chromosome 15.";
RL   Nature 440:671-675(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000453780}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
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DR   EMBL; AC046168; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC105133; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC110607; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H0YMX3; -.
DR   PeptideAtlas; H0YMX3; -.
DR   PRIDE; H0YMX3; -.
DR   Ensembl; ENST00000557798; ENSP00000453780; ENSG00000169783.
DR   UCSC; uc059lzv.1; human.
DR   EuPathDB; HostDB:ENSG00000169783.12; -.
DR   HGNC; HGNC:21205; LINGO1.
DR   OpenTargets; ENSG00000169783; -.
DR   eggNOG; KOG0619; Eukaryota.
DR   eggNOG; COG4886; LUCA.
DR   GeneTree; ENSGT00940000154996; -.
DR   ChiTaRS; LINGO1; human.
DR   Proteomes; UP000005640; Chromosome 15.
DR   Bgee; ENSG00000169783; Expressed in 172 organ(s), highest expression level in temporal lobe.
DR   ExpressionAtlas; H0YMX3; baseline and differential.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR000372; LRRNT.
DR   Pfam; PF13855; LRR_8; 2.
DR   SMART; SM00369; LRR_TYP; 7.
DR   SMART; SM00013; LRRNT; 1.
DR   PROSITE; PS51450; LRR; 8.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Leucine-rich repeat {ECO:0000256|SAAS:SAAS00138699};
KW   Proteomics identification {ECO:0000213|MaxQB:H0YMX3,
KW   ECO:0000213|PeptideAtlas:H0YMX3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00490532};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     46       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        47    326       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003546006.
FT   DOMAIN       46     80       LRRNT. {ECO:0000259|SMART:SM00013}.
FT   NON_TER     326    326       {ECO:0000313|Ensembl:ENSP00000453780}.
SQ   SEQUENCE   326 AA;  36715 MW;  D75C7324FC0E9B2D CRC64;
     MVQLEQKVSK RMLAGGVRSM PSPLLACWQP ILLLVLGSVL SGSATGCPPR CECSAQDRAV
     LCHRKRFVAV PEGIPTETRL LDLGKNRIKT LNQDEFASFP HLEELELNEN IVSAVEPGAF
     NNLFNLRTLG LRSNRLKLIP LGVFTGLSNL TKLDISENKI VILLDYMFQD LYNLKSLEVG
     DNDLVYISHR AFSGLNSLEQ LTLEKCNLTS IPTEALSHLH GLIVLRLRHL NINAIRDYSF
     KRLYRLKVLE ISHWPYLDTM TPNCLYGLNL TSLSITHCNL TAVPYLAVRH LVYLRFLNLS
     YNPISTIEGS MLHELLRLQE IQLVGG
//