ID   H0YMV0_HUMAN            Unreviewed;       219 AA.
AC   H0YMV0;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   05-DEC-2018, entry version 43.
DE   SubName: Full=Semaphorin-6D {ECO:0000313|Ensembl:ENSP00000453755};
DE   Flags: Fragment;
GN   Name=SEMA6D {ECO:0000313|Ensembl:ENSP00000453755};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000453755, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000453755, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16572171; DOI=10.1038/nature04601;
RA   Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA   Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA   Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA   Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA   DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R.,
RA   Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G.,
RA   Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A.,
RA   Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W.,
RA   Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X.,
RA   Sneddon K.M., Stewart S., Sougnez C., Stone S.M., Topham K.,
RA   Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S.,
RA   Nusbaum C.;
RT   "Analysis of the DNA sequence and duplication history of human
RT   chromosome 15.";
RL   Nature 440:671-675(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000453755}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR   EMBL; AC009558; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC012050; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC023905; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC044787; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC066615; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC084882; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KC877554; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF456040; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H0YMV0; -.
DR   SMR; H0YMV0; -.
DR   PeptideAtlas; H0YMV0; -.
DR   PRIDE; H0YMV0; -.
DR   Ensembl; ENST00000559196; ENSP00000453755; ENSG00000137872.
DR   UCSC; uc059iwn.1; human.
DR   EuPathDB; HostDB:ENSG00000137872.15; -.
DR   HGNC; HGNC:16770; SEMA6D.
DR   OpenTargets; ENSG00000137872; -.
DR   eggNOG; KOG3611; Eukaryota.
DR   eggNOG; ENOG410XQZC; LUCA.
DR   GeneTree; ENSGT00940000159303; -.
DR   ChiTaRS; SEMA6D; human.
DR   Proteomes; UP000005640; Chromosome 15.
DR   Bgee; ENSG00000137872; Expressed in 199 organ(s), highest expression level in forebrain.
DR   ExpressionAtlas; H0YMV0; baseline and differential.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR001627; Semap_dom.
DR   InterPro; IPR036352; Semap_dom_sf.
DR   InterPro; IPR027231; Semaphorin.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR11036; PTHR11036; 1.
DR   Pfam; PF01403; Sema; 1.
DR   SUPFAM; SSF101912; SSF101912; 1.
DR   PROSITE; PS51004; SEMA; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:H0YMV0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21    219       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003546230.
FT   DOMAIN       27    219       Sema. {ECO:0000259|PROSITE:PS51004}.
FT   NON_TER     219    219       {ECO:0000313|Ensembl:ENSP00000453755}.
SQ   SEQUENCE   219 AA;  25427 MW;  196EF96992E75728 CRC64;
     MRVFLLCAYI LLLMVSQLRA VSFPEDDEPL NTVDYHYSRQ YPVFRGRPSG NESQHRLDFQ
     LMLKIRDTLY IAGRDQVYTV NLNEMPKTEV IPNKKLTWRS RQQDRENCAM KGKHKDECHN
     FIKVFVPRND EMVFVCGTNA FNPMCRYYRL STLEYDGEEI SGLARCPFDA RQTNVALFAD
     GKLYSATVAD FLASDAVIYR SMGDGSALRT IKYDSKWIK
//