ID H0YMD1_HUMAN Unreviewed; 948 AA. AC H0YMD1; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-FEB-2012, sequence version 1. DT 16-JAN-2019, entry version 59. DE SubName: Full=Low-density lipoprotein receptor {ECO:0000313|Ensembl:ENSP00000453557}; GN Name=LDLR {ECO:0000313|Ensembl:ENSP00000453557}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000453557, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000453557, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15057824; DOI=10.1038/nature02399; RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., RA Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., RA Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., RA Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M., RA Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., RA Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., RA Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., RA Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., RA Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., RA Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., RA Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., RA Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., RA Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., RA Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., RA Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., RA Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., RA Rubin E.M., Lucas S.M.; RT "The DNA sequence and biology of human chromosome 19."; RL Nature 428:529-535(2004). RN [2] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [3] {ECO:0000313|Ensembl:ENSP00000453557} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. RN [4] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [5] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC011485; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF456500; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H0YMD1; -. DR EPD; H0YMD1; -. DR jPOST; H0YMD1; -. DR MaxQB; H0YMD1; -. DR PeptideAtlas; H0YMD1; -. DR PRIDE; H0YMD1; -. DR Ensembl; ENST00000557933; ENSP00000453557; ENSG00000130164. DR UCSC; uc060toi.1; human. DR EuPathDB; HostDB:ENSG00000130164.11; -. DR HGNC; HGNC:6547; LDLR. DR OpenTargets; ENSG00000130164; -. DR eggNOG; ENOG410IPSW; Eukaryota. DR eggNOG; ENOG410Z5FJ; LUCA. DR GeneTree; ENSGT00940000161046; -. DR ChiTaRS; LDLR; human. DR Proteomes; UP000005640; Chromosome 19. DR Bgee; ENSG00000130164; Expressed in 222 organ(s), highest expression level in adrenal tissue. DR ExpressionAtlas; H0YMD1; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR CDD; cd00112; LDLa; 7. DR Gene3D; 2.120.10.30; -; 1. DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like. DR InterPro; IPR001881; EGF-like_Ca-bd_dom. DR InterPro; IPR013032; EGF-like_CS. DR InterPro; IPR000742; EGF-like_dom. DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site. DR InterPro; IPR018097; EGF_Ca-bd_CS. DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf. DR InterPro; IPR036055; LDL_receptor-like_sf. DR InterPro; IPR023415; LDLR_class-A_CS. DR InterPro; IPR000033; LDLR_classB_rpt. DR InterPro; IPR002172; LDrepeatLR_classA_rpt. DR Pfam; PF07645; EGF_CA; 1. DR Pfam; PF00057; Ldl_recept_a; 7. DR Pfam; PF00058; Ldl_recept_b; 5. DR PRINTS; PR00261; LDLRECEPTOR. DR SMART; SM00181; EGF; 3. DR SMART; SM00179; EGF_CA; 2. DR SMART; SM00192; LDLa; 7. DR SMART; SM00135; LY; 5. DR SUPFAM; SSF57184; SSF57184; 1. DR SUPFAM; SSF57424; SSF57424; 7. DR PROSITE; PS00010; ASX_HYDROXYL; 2. DR PROSITE; PS01186; EGF_2; 2. DR PROSITE; PS50026; EGF_3; 2. DR PROSITE; PS01187; EGF_CA; 1. DR PROSITE; PS01209; LDLRA_1; 3. DR PROSITE; PS50068; LDLRA_2; 7. DR PROSITE; PS51120; LDLRB; 5. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00124, KW ECO:0000256|SAAS:SAAS00601599}; KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076, KW ECO:0000256|SAAS:SAAS00032677}; KW Membrane {ECO:0000256|SAAS:SAAS00492819}; KW Proteomics identification {ECO:0000213|EPD:H0YMD1, KW ECO:0000213|MaxQB:H0YMD1, ECO:0000213|PeptideAtlas:H0YMD1}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Repeat {ECO:0000256|SAAS:SAAS00594563}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00492819}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00492819}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 948 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003546524. FT DOMAIN 314 353 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 354 393 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT REPEAT 439 485 LDL-receptor class B. FT {ECO:0000256|PROSITE-ProRule:PRU00461}. FT REPEAT 486 528 LDL-receptor class B. FT {ECO:0000256|PROSITE-ProRule:PRU00461}. FT REPEAT 529 572 LDL-receptor class B. FT {ECO:0000256|PROSITE-ProRule:PRU00461}. FT REPEAT 573 617 LDL-receptor class B. FT {ECO:0000256|PROSITE-ProRule:PRU00461}. FT REPEAT 618 658 LDL-receptor class B. FT {ECO:0000256|PROSITE-ProRule:PRU00461}. FT DISULFID 27 39 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 34 52 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 89 104 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 109 121 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 116 134 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 128 143 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 148 160 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 155 173 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 197 209 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 204 222 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 216 231 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 236 248 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 243 261 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 255 270 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 284 302 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 358 368 {ECO:0000256|PROSITE-ProRule:PRU00076}. SQ SEQUENCE 948 AA; 104755 MW; 57F7301BE93FF20F CRC64; MGPWGWKLRW TVALLLAAAG TAVGDRCERN EFQCQDGKCI SYKWVCDGSA ECQDGSDESQ ETCLSVTCKS GDFSCGGRVN RCIPQFWRCD GQVDCDNGSD EQGCPPKTCS QDEFRCHDGK CISRQFVCDS DRDCLDGSDE ASCPVLTCGP ASFQCNSSTC IPQLWACDND PDCEDGSDEW PQRCRGLYVF QGDSSPCSAF EFHCLSGECI HSSWRCDGGP DCKDKSDEEN CAVATCRPDE FQCSDGNCIH GSRQCDREYD CKDMSDEVGC VNVTLCEGPN KFKCHSGECI TLDKVCNMAR DCRDWSDEPI KECGTNECLD NNGGCSHVCN DLKIGYECLC PDGFQLVAQR RCEDIDECQD PDTCSQLCVN LEGGYKCQCE EGFQLDPHTK ACKAVGSIAY LFFTNRHEVR KMTLDRSEYT SLIPNLRNVV ALDTEVASNR IYWSDLSQRM ICSTQLDRAH GVSSYDTVIS RDIQAPDGLA VDWIHSNIYW TDSVLGTVSV ADTKGVKRKT LFRENGSKPR AIVVDPVHGF MYWTDWGTPA KIKKGGLNGV DIYSLVTENI QWPNGITLDL LSGRLYWVDS KLHSISSIDV NGGNRKTILE DEKRLAHPFS LAVFEDKVFW TDIINEAIFS ANRLTGSDVN LLAENLLSPE DMVLFHNLTQ PRGVNWCERT TLSNGGCQYL CLPAPQINPH SPKFTCACPD GMLLARDMRS CLTEAEAAVA TQETSTVRLK VSSTAVRTQH TTTRPVPDTS RLPGATPGLT TVEIVTMSHQ ALGDVAGRGN EKKPSSVRAL SIVLPIATEL GLWSRGQLCD RACLSLQCSS SSFAWGSSFY GRTGGLRTST ASTLTTPSIR RPQRMRSTFA TTRTATATPR DRWSVWRMTW REHLPGVPSL PRTLPETSPA LFYSKTEKTK ALPARALFYI FIHLGGRTGF GQCPCNGLGW DFGFFLSS //