ID   H0YM39_HUMAN            Unreviewed;       160 AA.
AC   H0YM39;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   16-JAN-2019, entry version 46.
DE   SubName: Full=Chorionic somatomammotropin hormone 2 {ECO:0000313|Ensembl:ENSP00000453452};
GN   Name=CSH2 {ECO:0000313|Ensembl:ENSP00000453452};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000453452, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000453452, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000453452}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU003618,
CC       ECO:0000256|SAAS:SAAS00687159}.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000256|RuleBase:RU003618, ECO:0000256|SAAS:SAAS00680088}.
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DR   EMBL; AC015651; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H0YM39; -.
DR   PeptideAtlas; H0YM39; -.
DR   PRIDE; H0YM39; -.
DR   Ensembl; ENST00000560142; ENSP00000453452; ENSG00000213218.
DR   UCSC; uc060isn.1; human.
DR   EuPathDB; HostDB:ENSG00000213218.9; -.
DR   HGNC; HGNC:2441; CSH2.
DR   OpenTargets; ENSG00000213218; -.
DR   eggNOG; ENOG410IFR6; Eukaryota.
DR   eggNOG; ENOG4111HU8; LUCA.
DR   GeneTree; ENSGT00730000111012; -.
DR   ChiTaRS; CSH2; human.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000213218; Expressed in 33 organ(s), highest expression level in placenta.
DR   ExpressionAtlas; H0YM39; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 2.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00835087};
KW   Hormone {ECO:0000256|RuleBase:RU003618};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Secreted {ECO:0000256|SAAS:SAAS00119356};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     24       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        25    160       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003546058.
SQ   SEQUENCE   160 AA;  18364 MW;  9B1464D6551806AE CRC64;
     MAAGSRTSLL LAFALLCLPW LQEADSIPTP SNMEETQQKS NLELLRISLL LIESWLEPVR
     FLRSMFANNL VYDTSDSDDY HLLKDLEEGI QTLMGRLEDG SRRTGQILKQ TYSKFDTNSH
     NHDALLKNYG LLYCFRKDMD KVETFLRMVQ CRSVEGSCGF
//