ID   H0YLZ0_HUMAN            Unreviewed;       122 AA.
AC   H0YLZ0;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   05-DEC-2018, entry version 39.
DE   SubName: Full=Sodium/potassium/calcium exchanger 5 {ECO:0000313|Ensembl:ENSP00000453395};
GN   Name=SLC24A5 {ECO:0000313|Ensembl:ENSP00000453395};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000453395, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000453395, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16572171; DOI=10.1038/nature04601;
RA   Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA   Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA   Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA   Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA   DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R.,
RA   Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G.,
RA   Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A.,
RA   Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W.,
RA   Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X.,
RA   Sneddon K.M., Stewart S., Sougnez C., Stone S.M., Topham K.,
RA   Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S.,
RA   Nusbaum C.;
RT   "Analysis of the DNA sequence and duplication history of human
RT   chromosome 15.";
RL   Nature 440:671-675(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000453395}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
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DR   EMBL; AC090526; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PRIDE; H0YLZ0; -.
DR   Ensembl; ENST00000482911; ENSP00000453395; ENSG00000188467.
DR   UCSC; uc001zwd.4; human.
DR   EuPathDB; HostDB:ENSG00000188467.10; -.
DR   HGNC; HGNC:20611; SLC24A5.
DR   OpenTargets; ENSG00000188467; -.
DR   eggNOG; KOG1307; Eukaryota.
DR   eggNOG; ENOG410Y9YY; LUCA.
DR   GeneTree; ENSGT00940000156520; -.
DR   ChiTaRS; SLC24A5; human.
DR   Proteomes; UP000005640; Chromosome 15.
DR   Bgee; ENSG00000188467; Expressed in 38 organ(s), highest expression level in skin of abdomen.
DR   ExpressionAtlas; H0YLZ0; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005802; C:trans-Golgi network; IEA:InterPro.
DR   GO; GO:0008273; F:calcium, potassium:sodium antiporter activity; IEA:InterPro.
DR   GO; GO:0048021; P:regulation of melanin biosynthetic process; IEA:InterPro.
DR   InterPro; IPR004481; K/Na/Ca-exchanger.
DR   InterPro; IPR030245; SLC24A5.
DR   PANTHER; PTHR10846; PTHR10846; 1.
DR   PANTHER; PTHR10846:SF27; PTHR10846:SF27; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     29       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        30    122       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003546517.
FT   TRANSMEM     69     92       Helical. {ECO:0000256|SAM:Phobius}.
SQ   SEQUENCE   122 AA;  13906 MW;  7293BBD4A3D3F235 CRC64;
     MQTKGGQTWA RRALLLGILW ATAHLPLSGT SLPQRLPRAT GNSTQCVISP SSEFPEGFFT
     RQERRDGGII IYFLIIVYMF MAISIVCDEY FLPSLEIISE CKWLESCPVT FWESVPHRYD
     CL
//