ID   H0YLK8_HUMAN            Unreviewed;       297 AA.
AC   H0YLK8;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   16-JAN-2019, entry version 43.
DE   SubName: Full=Clusterin {ECO:0000313|Ensembl:ENSP00000453247};
DE   Flags: Fragment;
GN   Name=CLU {ECO:0000313|Ensembl:ENSP00000453247};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000453247, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000453247, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S.,
RA   Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A.,
RA   Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA   Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T.,
RA   Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K.,
RA   DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Glockner G.,
RA   Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B.,
RA   Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C.,
RA   O'Leary S.B., O'Neill K., Parker S.C., Polley A., Raymond C.K.,
RA   Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R.,
RA   Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K.,
RA   Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q.,
RA   Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N.,
RA   Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000453247}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
RN   [3] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
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DR   EMBL; AF311103; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H0YLK8; -.
DR   SMR; H0YLK8; -.
DR   jPOST; H0YLK8; -.
DR   MaxQB; H0YLK8; -.
DR   PeptideAtlas; H0YLK8; -.
DR   PRIDE; H0YLK8; -.
DR   Ensembl; ENST00000560566; ENSP00000453247; ENSG00000120885.
DR   UCSC; uc064llw.1; human.
DR   EuPathDB; HostDB:ENSG00000120885.19; -.
DR   HGNC; HGNC:2095; CLU.
DR   OpenTargets; ENSG00000120885; -.
DR   eggNOG; ENOG410IHRB; Eukaryota.
DR   eggNOG; ENOG410YYKB; LUCA.
DR   GeneTree; ENSGT00530000063668; -.
DR   ChiTaRS; CLU; human.
DR   Proteomes; UP000005640; Chromosome 8.
DR   Bgee; ENSG00000120885; Expressed in 238 organ(s), highest expression level in tendon of biceps brachii.
DR   ExpressionAtlas; H0YLK8; baseline and differential.
DR   InterPro; IPR016016; Clusterin.
DR   InterPro; IPR000753; Clusterin-like.
DR   InterPro; IPR033986; Clusterin_CS.
DR   InterPro; IPR016014; Clusterin_N.
DR   PANTHER; PTHR10970; PTHR10970; 1.
DR   PANTHER; PTHR10970:SF1; PTHR10970:SF1; 1.
DR   Pfam; PF01093; Clusterin; 1.
DR   SMART; SM00030; CLb; 1.
DR   PROSITE; PS00492; CLUSTERIN_1; 1.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:H0YLK8,
KW   ECO:0000213|MaxQB:H0YLK8, ECO:0000213|PeptideAtlas:H0YLK8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     33       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        34    297       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003546046.
FT   DOMAIN       34    238       CLb. {ECO:0000259|SMART:SM00030}.
FT   COILED       64    105       {ECO:0000256|SAM:Coils}.
FT   NON_TER     297    297       {ECO:0000313|Ensembl:ENSP00000453247}.
SQ   SEQUENCE   297 AA;  34749 MW;  3E332849B9E4B82D CRC64;
     MEACKDSRIG GMMKTLLLFV GLLLTWESGQ VLGDQTVSDN ELQEMSNQGS KYVNKEIQNA
     VNGVKQIKTL IEKTNEERKT LLSNLEEAKK KKEDALNETR ESETKLKELP GVCNETMMAL
     WEECKPCLKQ TCMKFYARVC RSGSGLVGRQ LEEFLNQSSP FYFWMNGDRI DSLLENDRQQ
     THMLDVMQDH FSRASSIIDE LFQDRFFTRE PQDTYHYLPF SLPHRRPHFF FPKSRIVRSL
     MPFSPYEPLN FHAMFQPFLE MIHEAQQAMD IHFHSPAFQH PPTEFIREGD DDRTVCR
//