ID   H0YLH7_HUMAN            Unreviewed;       175 AA.
AC   H0YLH7;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   05-DEC-2018, entry version 48.
DE   SubName: Full=Furin {ECO:0000313|Ensembl:ENSP00000453212};
DE   Flags: Fragment;
GN   Name=FURIN {ECO:0000313|Ensembl:ENSP00000453212};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000453212, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000453212, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16572171; DOI=10.1038/nature04601;
RA   Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA   Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA   Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA   Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA   DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R.,
RA   Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G.,
RA   Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A.,
RA   Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W.,
RA   Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X.,
RA   Sneddon K.M., Stewart S., Sougnez C., Stone S.M., Topham K.,
RA   Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S.,
RA   Nusbaum C.;
RT   "Analysis of the DNA sequence and duplication history of human
RT   chromosome 15.";
RL   Nature 440:671-675(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000453212}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
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DR   EMBL; AC124248; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H0YLH7; -.
DR   EPD; H0YLH7; -.
DR   MaxQB; H0YLH7; -.
DR   PeptideAtlas; H0YLH7; -.
DR   PRIDE; H0YLH7; -.
DR   Ensembl; ENST00000560824; ENSP00000453212; ENSG00000140564.
DR   UCSC; uc059ngo.1; human.
DR   EuPathDB; HostDB:ENSG00000140564.10; -.
DR   HGNC; HGNC:8568; FURIN.
DR   OpenTargets; ENSG00000140564; -.
DR   eggNOG; KOG3525; Eukaryota.
DR   eggNOG; COG1404; LUCA.
DR   eggNOG; COG4935; LUCA.
DR   GeneTree; ENSGT00940000157220; -.
DR   ChiTaRS; FURIN; human.
DR   Proteomes; UP000005640; Chromosome 15.
DR   Bgee; ENSG00000140564; Expressed in 223 organ(s), highest expression level in right lobe of liver.
DR   ExpressionAtlas; H0YLH7; baseline and differential.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   Gene3D; 3.30.70.850; -; 1.
DR   Gene3D; 3.40.50.200; -; 1.
DR   InterPro; IPR000209; Peptidase_S8/S53_dom.
DR   InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR   InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR   InterPro; IPR032815; S8_pro-domain.
DR   InterPro; IPR038466; S8_pro-domain_sf.
DR   Pfam; PF00082; Peptidase_S8; 1.
DR   Pfam; PF16470; S8_pro-domain; 1.
DR   SUPFAM; SSF52743; SSF52743; 1.
DR   PROSITE; PS00136; SUBTILASE_ASP; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:H0YLH7,
KW   ECO:0000213|PeptideAtlas:H0YLH7};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     26       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        27    175       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003546200.
FT   DOMAIN       33    105       S8_pro-domain.
FT                                {ECO:0000259|Pfam:PF16470}.
FT   DOMAIN      142    172       Peptidase S8. {ECO:0000259|Pfam:PF00082}.
FT   NON_TER     175    175       {ECO:0000313|Ensembl:ENSP00000453212}.
SQ   SEQUENCE   175 AA;  19838 MW;  31AB6C8C23D3D24D CRC64;
     MELRPWLLWV VAATGTLVLL AADAQGQKVF TNTWAVRIPG GPAVANSVAR KHGFLNLGQI
     FGDYYHFWHR GVTKRSLSPH RPRHSRLQRE PQWLEQQVAK RRTKRDVYQE PTDPKFPQQW
     YLSGVTQRDL NVKAAWAQGY TGHGIVVSIL DDGIEKNHPD LAGNYDPGAS FDVND
//