ID   H0YL90_HUMAN            Unreviewed;       183 AA.
AC   H0YL90;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   16-JAN-2019, entry version 50.
DE   SubName: Full=Immunoglobulin superfamily-containing leucine-rich repeat protein {ECO:0000313|Ensembl:ENSP00000453105};
DE   Flags: Fragment;
GN   Name=ISLR {ECO:0000313|Ensembl:ENSP00000453105};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000453105, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000453105, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16572171; DOI=10.1038/nature04601;
RA   Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA   Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA   Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA   Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA   DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R.,
RA   Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G.,
RA   Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A.,
RA   Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W.,
RA   Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X.,
RA   Sneddon K.M., Stewart S., Sougnez C., Stone S.M., Topham K.,
RA   Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S.,
RA   Nusbaum C.;
RT   "Analysis of the DNA sequence and duplication history of human
RT   chromosome 15.";
RL   Nature 440:671-675(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000453105}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
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DR   EMBL; AC023545; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H0YL90; -.
DR   jPOST; H0YL90; -.
DR   PeptideAtlas; H0YL90; -.
DR   PRIDE; H0YL90; -.
DR   Ensembl; ENST00000560862; ENSP00000453105; ENSG00000129009.
DR   UCSC; uc059lgx.1; human.
DR   EuPathDB; HostDB:ENSG00000129009.12; -.
DR   HGNC; HGNC:6133; ISLR.
DR   OpenTargets; ENSG00000129009; -.
DR   eggNOG; KOG0619; Eukaryota.
DR   eggNOG; COG4886; LUCA.
DR   GeneTree; ENSGT00940000160967; -.
DR   ChiTaRS; ISLR; human.
DR   Proteomes; UP000005640; Chromosome 15.
DR   Bgee; ENSG00000129009; Expressed in 184 organ(s), highest expression level in endocervix.
DR   ExpressionAtlas; H0YL90; baseline and differential.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   Pfam; PF13855; LRR_8; 2.
DR   SMART; SM00369; LRR_TYP; 5.
DR   PROSITE; PS51450; LRR; 5.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:H0YL90,
KW   ECO:0000213|PeptideAtlas:H0YL90};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19    183       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003546741.
FT   NON_TER     183    183       {ECO:0000313|Ensembl:ENSP00000453105}.
SQ   SEQUENCE   183 AA;  20333 MW;  EC1F60C077975587 CRC64;
     MQELHLLWWA LLLGLAQACP EPCDCGEKYG FQIADCAYRD LESVPPGFPA NVTTLSLSAN
     RLPGLPEGAF REVPLLQSLW LAHNEIRTVA AGALASLSHL KSLDLSHNLI SDFAWSDLHN
     LSALQLLKMD SNELTFIPRD AFRSLRALRS LQLNHNRLHT LAEGTFTPLT ALSHLQINEN
     PFD
//