ID   H0YL43_HUMAN            Unreviewed;       155 AA.
AC   H0YL43;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   16-JAN-2019, entry version 46.
DE   SubName: Full=Reticulocalbin-2 {ECO:0000313|Ensembl:ENSP00000453052};
DE   Flags: Fragment;
GN   Name=RCN2 {ECO:0000313|Ensembl:ENSP00000453052};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000453052, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000453052, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16572171; DOI=10.1038/nature04601;
RA   Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA   Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA   Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA   Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA   DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R.,
RA   Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G.,
RA   Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A.,
RA   Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W.,
RA   Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X.,
RA   Sneddon K.M., Stewart S., Sougnez C., Stone S.M., Topham K.,
RA   Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S.,
RA   Nusbaum C.;
RT   "Analysis of the DNA sequence and duplication history of human
RT   chromosome 15.";
RL   Nature 440:671-675(2006).
RN   [2] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0000313|Ensembl:ENSP00000453052}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
RN   [4] {ECO:0000213|PubMed:23186163}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=23186163;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
RN   [5] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
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DR   EMBL; AC051643; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H0YL43; -.
DR   jPOST; H0YL43; -.
DR   MaxQB; H0YL43; -.
DR   PeptideAtlas; H0YL43; -.
DR   PRIDE; H0YL43; -.
DR   Ensembl; ENST00000557805; ENSP00000453052; ENSG00000117906.
DR   UCSC; uc059lxr.1; human.
DR   EuPathDB; HostDB:ENSG00000117906.13; -.
DR   HGNC; HGNC:9935; RCN2.
DR   OpenTargets; ENSG00000117906; -.
DR   eggNOG; KOG4223; Eukaryota.
DR   eggNOG; ENOG410XRVE; LUCA.
DR   GeneTree; ENSGT00940000153732; -.
DR   ChiTaRS; RCN2; human.
DR   Proteomes; UP000005640; Chromosome 15.
DR   Bgee; ENSG00000117906; Expressed in 248 organ(s), highest expression level in caput epididymis.
DR   ExpressionAtlas; H0YL43; baseline and differential.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS00018; EF_HAND_1; 2.
DR   PROSITE; PS50222; EF_HAND_2; 2.
PE   1: Evidence at protein level;
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU00448};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:H0YL43,
KW   ECO:0000213|MaxQB:H0YL43, ECO:0000213|PeptideAtlas:H0YL43};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     16       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        17    155       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003546192.
FT   DOMAIN       52     87       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   DOMAIN       88    123       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   CA_BIND      65     76       {ECO:0000256|PROSITE-ProRule:PRU00448}.
FT   CA_BIND     101    112       {ECO:0000256|PROSITE-ProRule:PRU00448}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSP00000453052}.
SQ   SEQUENCE   155 AA;  17721 MW;  338A0E87766C84FA CRC64;
     XGLLLLCAAA AGAGKAEELH YPLGERRSDY DREALLGVQE DVDEYVKLGH EEQQKRLQAI
     IKKIDLDSDG FLTESELSSW IQMSFKHYAM QEAKQQFVEY DKNSDDTVTW DEYNIQMYDR
     VIDFDENTAL DDAEEESFRK HQCGGLGLHP QSQSA
//