ID   H0YKS8_HUMAN            Unreviewed;       268 AA.
AC   H0YKS8;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   16-JAN-2019, entry version 48.
DE   SubName: Full=Lactadherin {ECO:0000313|Ensembl:ENSP00000452926};
DE   Flags: Fragment;
GN   Name=MFGE8 {ECO:0000313|Ensembl:ENSP00000452926};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000452926, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000452926, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16572171; DOI=10.1038/nature04601;
RA   Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA   Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA   Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA   Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA   DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R.,
RA   Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G.,
RA   Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A.,
RA   Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W.,
RA   Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X.,
RA   Sneddon K.M., Stewart S., Sougnez C., Stone S.M., Topham K.,
RA   Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S.,
RA   Nusbaum C.;
RT   "Analysis of the DNA sequence and duplication history of human
RT   chromosome 15.";
RL   Nature 440:671-675(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000452926}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   EMBL; AC067805; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H0YKS8; -.
DR   SMR; H0YKS8; -.
DR   EPD; H0YKS8; -.
DR   jPOST; H0YKS8; -.
DR   MaxQB; H0YKS8; -.
DR   PeptideAtlas; H0YKS8; -.
DR   PRIDE; H0YKS8; -.
DR   Ensembl; ENST00000558029; ENSP00000452926; ENSG00000140545.
DR   UCSC; uc059myl.1; human.
DR   EuPathDB; HostDB:ENSG00000140545.14; -.
DR   HGNC; HGNC:7036; MFGE8.
DR   OpenTargets; ENSG00000140545; -.
DR   eggNOG; ENOG410IFBC; Eukaryota.
DR   eggNOG; ENOG41114BV; LUCA.
DR   GeneTree; ENSGT00940000156049; -.
DR   ChiTaRS; MFGE8; human.
DR   Proteomes; UP000005640; Chromosome 15.
DR   Bgee; ENSG00000140545; Expressed in 207 organ(s), highest expression level in descending thoracic aorta.
DR   ExpressionAtlas; H0YKS8; baseline and differential.
DR   CDD; cd00057; FA58C; 1.
DR   Gene3D; 2.60.120.260; -; 1.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000421; FA58C.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR027060; Lactadherin.
DR   PANTHER; PTHR44122:SF1; PTHR44122:SF1; 2.
DR   Pfam; PF00008; EGF; 1.
DR   Pfam; PF00754; F5_F8_type_C; 1.
DR   SMART; SM00181; EGF; 1.
DR   SMART; SM00231; FA58C; 1.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   PROSITE; PS00022; EGF_1; 1.
DR   PROSITE; PS50026; EGF_3; 1.
DR   PROSITE; PS01285; FA58C_1; 1.
DR   PROSITE; PS01286; FA58C_2; 1.
DR   PROSITE; PS50022; FA58C_3; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW   Proteomics identification {ECO:0000213|EPD:H0YKS8,
KW   ECO:0000213|MaxQB:H0YKS8, ECO:0000213|PeptideAtlas:H0YKS8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24    268       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003546185.
FT   DOMAIN       23     67       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN       70    225       F5/8 type C.
FT                                {ECO:0000259|PROSITE:PS50022}.
FT   DISULFID     57     66       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   NON_TER     268    268       {ECO:0000313|Ensembl:ENSP00000452926}.
SQ   SEQUENCE   268 AA;  29168 MW;  FA019024AA4C62E3 CRC64;
     MPRPRLLAAL CGALLCAPSL LVALDICSKN PCHNGGLCEE ISQEVRGDVF PSYTCTCLKG
     YAGNHCETKC VEPLGLENGN IANSQIAASS VRVTFLGLQH WVPELARLNR AGMVNAWTPS
     SNDDNPWIQV NLLRRMWVTG VVTQGASRLA SHEYLKAFKV AYSLNGHEFD FIHDVNKKHK
     EFVGNWNKNA VHVNLFETPV EAQYVRLYPT SCHTACTLRF ELLGCELNAA TRPGACISSA
     GTPPMHGWTS RATSTPGLRG ATVTISGC
//