ID   H0YKJ9_HUMAN            Unreviewed;       164 AA.
AC   H0YKJ9;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   16-JAN-2019, entry version 45.
DE   SubName: Full=Tetraspanin-3 {ECO:0000313|Ensembl:ENSP00000452835};
GN   Name=TSPAN3 {ECO:0000313|Ensembl:ENSP00000452835};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000452835, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000452835, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16572171; DOI=10.1038/nature04601;
RA   Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA   Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA   Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA   Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA   DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R.,
RA   Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G.,
RA   Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A.,
RA   Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W.,
RA   Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X.,
RA   Sneddon K.M., Stewart S., Sougnez C., Stone S.M., Topham K.,
RA   Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S.,
RA   Nusbaum C.;
RT   "Analysis of the DNA sequence and duplication history of human
RT   chromosome 15.";
RL   Nature 440:671-675(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000452835}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family.
CC       {ECO:0000256|SAAS:SAAS00562291}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AC090181; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF510412; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H0YKJ9; -.
DR   SwissPalm; H0YKJ9; -.
DR   EPD; H0YKJ9; -.
DR   jPOST; H0YKJ9; -.
DR   PeptideAtlas; H0YKJ9; -.
DR   PRIDE; H0YKJ9; -.
DR   Ensembl; ENST00000559494; ENSP00000452835; ENSG00000140391.
DR   UCSC; uc059lyo.1; human.
DR   EuPathDB; HostDB:ENSG00000140391.14; -.
DR   HGNC; HGNC:17752; TSPAN3.
DR   OpenTargets; ENSG00000140391; -.
DR   eggNOG; KOG3882; Eukaryota.
DR   eggNOG; ENOG4111IRY; LUCA.
DR   GeneTree; ENSGT00940000154954; -.
DR   ChiTaRS; TSPAN3; human.
DR   Proteomes; UP000005640; Chromosome 15.
DR   Bgee; ENSG00000140391; Expressed in 231 organ(s), highest expression level in parietal pleura.
DR   ExpressionAtlas; H0YKJ9; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.1450.10; -; 1.
DR   InterPro; IPR018499; Tetraspanin/Peripherin.
DR   InterPro; IPR008952; Tetraspanin_EC2_sf.
DR   Pfam; PF00335; Tetraspanin; 1.
DR   SUPFAM; SSF48652; SSF48652; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAAS:SAAS00066888, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|MaxQB:H0YKJ9,
KW   ECO:0000213|PeptideAtlas:H0YKJ9};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00066888,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00066888,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     24       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        25    164       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003546181.
FT   TRANSMEM    123    146       Helical. {ECO:0000256|SAM:Phobius}.
SQ   SEQUENCE   164 AA;  18349 MW;  B0C0B65E6052F769 CRC64;
     MGQCGITSSK TVLVFLNLIF WVENEVDRSI QKVYKTYNGT NPDAASRAID YVQRQLHCCG
     IHNYSDWENT DWFKETKNQS VPLSCCRETA SNCNGSLAHP SDLYAEGCEA LVVKKLQEIM
     MHVIWAALAF AAIQLLGMLC ACIVLCRRSR DPAYELLITG GTYA
//