ID   H0YK87_HUMAN            Unreviewed;       115 AA.
AC   H0YK87;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   16-JAN-2019, entry version 46.
DE   SubName: Full=Disintegrin and metalloproteinase domain-containing protein 10 {ECO:0000313|Ensembl:ENSP00000452704};
DE   Flags: Fragment;
GN   Name=ADAM10 {ECO:0000313|Ensembl:ENSP00000452704};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000452704, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000452704, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16572171; DOI=10.1038/nature04601;
RA   Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA   Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA   Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA   Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA   DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R.,
RA   Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G.,
RA   Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A.,
RA   Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W.,
RA   Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X.,
RA   Sneddon K.M., Stewart S., Sougnez C., Stone S.M., Topham K.,
RA   Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S.,
RA   Nusbaum C.;
RT   "Analysis of the DNA sequence and duplication history of human
RT   chromosome 15.";
RL   Nature 440:671-675(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000452704}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
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DR   EMBL; AC018904; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC091046; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   jPOST; H0YK87; -.
DR   MaxQB; H0YK87; -.
DR   PeptideAtlas; H0YK87; -.
DR   PRIDE; H0YK87; -.
DR   Ensembl; ENST00000558004; ENSP00000452704; ENSG00000137845.
DR   UCSC; uc059jsa.1; human.
DR   EuPathDB; HostDB:ENSG00000137845.14; -.
DR   HGNC; HGNC:188; ADAM10.
DR   OpenTargets; ENSG00000137845; -.
DR   eggNOG; KOG3658; Eukaryota.
DR   eggNOG; ENOG410XQWB; LUCA.
DR   GeneTree; ENSGT00940000160579; -.
DR   ChiTaRS; ADAM10; human.
DR   Proteomes; UP000005640; Chromosome 15.
DR   Bgee; ENSG00000137845; Expressed in 242 organ(s), highest expression level in testis.
DR   ExpressionAtlas; H0YK87; baseline and differential.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006509; P:membrane protein ectodomain proteolysis; IEA:InterPro.
DR   GO; GO:0007219; P:Notch signaling pathway; IEA:InterPro.
DR   InterPro; IPR027053; ADAM_10.
DR   PANTHER; PTHR11905:SF4; PTHR11905:SF4; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:H0YK87,
KW   ECO:0000213|MaxQB:H0YK87, ECO:0000213|PeptideAtlas:H0YK87};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19    115       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003546493.
FT   NON_TER     115    115       {ECO:0000313|Ensembl:ENSP00000452704}.
SQ   SEQUENCE   115 AA;  13209 MW;  955D855BBE350573 CRC64;
     MVLLRVLILL LSWAAGMGGQ YGNPLNKYIR HYEGLSYNVD SLHQKHQRAK RAVSHEDQFL
     RLDFHAHGRD GVLPCCPGWS QTPGLKRSTC LSLPQCWDYR CEPSPMISVF DYPHK
//