ID   H0YK59_HUMAN            Unreviewed;       165 AA.
AC   H0YK59;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   16-JAN-2019, entry version 46.
DE   SubName: Full=CD276 antigen {ECO:0000313|Ensembl:ENSP00000452669};
DE   Flags: Fragment;
GN   Name=CD276 {ECO:0000313|Ensembl:ENSP00000452669};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000452669, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000452669, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16572171; DOI=10.1038/nature04601;
RA   Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA   Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA   Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA   Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA   DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R.,
RA   Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G.,
RA   Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A.,
RA   Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W.,
RA   Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X.,
RA   Sneddon K.M., Stewart S., Sougnez C., Stone S.M., Topham K.,
RA   Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S.,
RA   Nusbaum C.;
RT   "Analysis of the DNA sequence and duplication history of human
RT   chromosome 15.";
RL   Nature 440:671-675(2006).
RN   [2] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0000313|Ensembl:ENSP00000452669}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
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DR   EMBL; AC022188; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC100838; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H0YK59; -.
DR   jPOST; H0YK59; -.
DR   MaxQB; H0YK59; -.
DR   PeptideAtlas; H0YK59; -.
DR   PRIDE; H0YK59; -.
DR   Ensembl; ENST00000561260; ENSP00000452669; ENSG00000103855.
DR   UCSC; uc059lep.1; human.
DR   EuPathDB; HostDB:ENSG00000103855.17; -.
DR   HGNC; HGNC:19137; CD276.
DR   OpenTargets; ENSG00000103855; -.
DR   eggNOG; ENOG410IR2H; Eukaryota.
DR   eggNOG; ENOG410ZB69; LUCA.
DR   GeneTree; ENSGT00940000154641; -.
DR   ChiTaRS; CD276; human.
DR   Proteomes; UP000005640; Chromosome 15.
DR   Bgee; ENSG00000103855; Expressed in 188 organ(s), highest expression level in layer of synovial tissue.
DR   ExpressionAtlas; H0YK59; baseline and differential.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00406; IGv; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:H0YK59,
KW   ECO:0000213|MaxQB:H0YK59, ECO:0000213|PeptideAtlas:H0YK59};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     28       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        29    165       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003545980.
FT   DOMAIN       43    139       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   NON_TER     165    165       {ECO:0000313|Ensembl:ENSP00000452669}.
SQ   SEQUENCE   165 AA;  17572 MW;  340B526AD82F70DD CRC64;
     MLRRRGSPGM GVHVGAALGA LWFCLTGALE VQVPEDPVVA LVGTDATLCC SFSPEPGFSL
     AQLNLIWQLT DTKQLVHSFA EGQDQGSAYA NRTALFPDLL AQGNASLRLQ RVRVADEGSF
     TCFVSIRDFG SAAVSLQVAA PYSKPSMTLE PNKDLRPGDT VTITC
//