ID   H0YJ66_HUMAN            Unreviewed;       399 AA.
AC   H0YJ66;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   16-JAN-2019, entry version 55.
DE   SubName: Full=Dehydrogenase/reductase SDR family member 7 {ECO:0000313|Ensembl:ENSP00000450899};
DE   Flags: Fragment;
GN   Name=DHRS7 {ECO:0000313|Ensembl:ENSP00000450899};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000450899, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000450899, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12508121; DOI=10.1038/nature01348;
RA   Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA   Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA   Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S.,
RA   Sun H., Du H., Pepin K., Artiguenave F., Robert C., Cruaud C.,
RA   Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P.,
RA   Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N.,
RA   Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C.,
RA   Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S.,
RA   Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B.,
RA   Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M.,
RA   Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S.,
RA   Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D.,
RA   Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A.,
RA   Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA   Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA   Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L.,
RA   Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J.,
RA   Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W.,
RA   Quetier F., Waterston R., Hood L., Weissenbach J.;
RT   "The DNA sequence and analysis of human chromosome 14.";
RL   Nature 421:601-607(2003).
RN   [2] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0000313|Ensembl:ENSP00000450899}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
RN   [4] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
RN   [5] {ECO:0000213|PubMed:25944712}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25944712;
RA   Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
RA   Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT   "N-terminome analysis of the human mitochondrial proteome.";
RL   Proteomics 15:2519-2524(2015).
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases
CC       (SDR) family. {ECO:0000256|RuleBase:RU000363}.
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DR   EMBL; AL163853; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H0YJ66; -.
DR   EPD; H0YJ66; -.
DR   jPOST; H0YJ66; -.
DR   MaxQB; H0YJ66; -.
DR   PeptideAtlas; H0YJ66; -.
DR   PRIDE; H0YJ66; -.
DR   Ensembl; ENST00000554101; ENSP00000450899; ENSG00000100612.
DR   UCSC; uc059ccz.1; human.
DR   EuPathDB; HostDB:ENSG00000100612.13; -.
DR   HGNC; HGNC:21524; DHRS7.
DR   OpenTargets; ENSG00000100612; -.
DR   eggNOG; ENOG410IUBT; Eukaryota.
DR   eggNOG; COG0300; LUCA.
DR   GeneTree; ENSGT00940000155226; -.
DR   Proteomes; UP000005640; Chromosome 14.
DR   Bgee; ENSG00000100612; Expressed in 232 organ(s), highest expression level in gastrocnemius.
DR   ExpressionAtlas; H0YJ66; baseline and differential.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:H0YJ66,
KW   ECO:0000213|MaxQB:H0YJ66, ECO:0000213|PeptideAtlas:H0YJ66};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24    399       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003546479.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSP00000450899}.
SQ   SEQUENCE   399 AA;  44792 MW;  EC6C52DEA115AAF9 CRC64;
     XLWLLVLCAL LLLLVQLLRF LRADGDLTLL WAEWQGRRPE WELTDMVVWV TGASSGIGEE
     LAYQLSKLGV SLVLSARRVH ELERVKRRCL ENGNLKEKDI LVLPLDLTDT GSHEAATKAV
     LQEFGRIDIL VNNGGMSQRS LCMDTSLDVY RKLIELNYLG TVSLTKCVLP HMIERKQGKI
     VTVNSILGII SVPLSIGYCA SKHALRGFFN GLRTELATYP GIIVSNICPG PVQSNIVENS
     LAGEVTKTIG NNGDQSHKMT TSRCVRLMLI SMANDLKEVW ISEQPFLLVT YLWQYMPTWA
     WWITNKMGKK RIENFKSGVV RPISKFLNSM YQSCRKVQNF PVFKKLSGWV QWLMSVIPAL
     WEAKADHLRP GVQDQPGQHS ETPSLLKIQK VAGHGGACL
//