ID   H0YE23_HUMAN            Unreviewed;       159 AA.
AC   H0YE23;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   16-JAN-2019, entry version 39.
DE   SubName: Full=Tumor necrosis factor receptor superfamily member 5 {ECO:0000313|Ensembl:ENSP00000434825};
DE   Flags: Fragment;
GN   Name=CD40 {ECO:0000313|Ensembl:ENSP00000434825};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000434825, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000434825, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11780052; DOI=10.1038/414865a;
RA   Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA   Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA   Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M.,
RA   Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J.,
RA   Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P.,
RA   Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M.,
RA   Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R.,
RA   Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M.,
RA   Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA   Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA   Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA   Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA   Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA   Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA   Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA   Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA   Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H.,
RA   Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S.,
RA   Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E.,
RA   Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A.,
RA   Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M.,
RA   Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A.,
RA   Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S.,
RA   Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 20.";
RL   Nature 414:865-871(2001).
RN   [2] {ECO:0000313|Ensembl:ENSP00000434825}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00206}.
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DR   EMBL; AL035662; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H0YE23; -.
DR   jPOST; H0YE23; -.
DR   PeptideAtlas; H0YE23; -.
DR   PRIDE; H0YE23; -.
DR   Ensembl; ENST00000466205; ENSP00000434825; ENSG00000101017.
DR   UCSC; uc061xlp.1; human.
DR   EuPathDB; HostDB:ENSG00000101017.13; -.
DR   HGNC; HGNC:11919; CD40.
DR   OpenTargets; ENSG00000101017; -.
DR   eggNOG; ENOG410IY0H; Eukaryota.
DR   eggNOG; ENOG4112DB5; LUCA.
DR   GeneTree; ENSGT00940000161464; -.
DR   ChiTaRS; CD40; human.
DR   Proteomes; UP000005640; Chromosome 20.
DR   Bgee; ENSG00000101017; Expressed in 203 organ(s), highest expression level in left coronary artery.
DR   ExpressionAtlas; H0YE23; baseline and differential.
DR   GO; GO:0009897; C:external side of plasma membrane; IEA:InterPro.
DR   GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR   GO; GO:0042113; P:B cell activation; IEA:InterPro.
DR   GO; GO:0050776; P:regulation of immune response; IEA:InterPro.
DR   InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR   InterPro; IPR020435; TNFR_5.
DR   Pfam; PF00020; TNFR_c6; 1.
DR   PRINTS; PR01922; TNFACTORR5.
DR   SMART; SM00208; TNFR; 3.
DR   PROSITE; PS00652; TNFR_NGFR_1; 1.
DR   PROSITE; PS50050; TNFR_NGFR_2; 2.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00206};
KW   Proteomics identification {ECO:0000213|MaxQB:H0YE23,
KW   ECO:0000213|PeptideAtlas:H0YE23};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20    159       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003546454.
FT   DOMAIN       24     58       TNFR-Cys. {ECO:0000259|PROSITE:PS50050}.
FT   REPEAT       24     58       TNFR-Cys. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00206}.
FT   DOMAIN       60    102       TNFR-Cys. {ECO:0000259|PROSITE:PS50050}.
FT   REPEAT       60    102       TNFR-Cys. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00206}.
FT   DISULFID     37     50       {ECO:0000256|PROSITE-ProRule:PRU00206}.
FT   DISULFID     40     58       {ECO:0000256|PROSITE-ProRule:PRU00206}.
FT   DISULFID     61     76       {ECO:0000256|PROSITE-ProRule:PRU00206}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSP00000434825}.
SQ   SEQUENCE   159 AA;  17914 MW;  CC40F2DACEBDEC23 CRC64;
     XRLPLQCVLW GCLLTAVHPE PPTACREKQY LINSQCCSLC QPGQKLVSDC TEFTETECLP
     CGESEFLDTW NRETHCHQHK YCDPNLGLRV QQKGTSETDT ICTCEEGWHC TSEACESCVL
     HRSCSPGFGV KQIAVRPKTW LCNRQAQTRL MLSVVPRIG
//