ID   H0YE06_HUMAN            Unreviewed;       660 AA.
AC   H0YE06;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 8.
DT   16-JAN-2019, entry version 50.
DE   SubName: Full=Complement receptor type 1 {ECO:0000313|Ensembl:ENSP00000434718};
DE   Flags: Fragment;
GN   Name=CR1 {ECO:0000313|Ensembl:ENSP00000434718};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000434718, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000434718, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA   Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.,
RA   Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA   McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA   Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I., Aubin K.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA   Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA   Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA   Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA   Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA   Hammond S., Harrison E.S., Hart E., Haugen E., Heath P.D., Holmes S.,
RA   Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J.,
RA   James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K.,
RA   Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G.,
RA   Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J.,
RA   Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L.,
RA   Matthews N.S., McLaren S., Milne S., Mistry S., Moore M.J.,
RA   Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A.,
RA   Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K.,
RA   Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G.,
RA   Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S.,
RA   Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N.,
RA   Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S.,
RA   Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L.,
RA   Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.,
RA   Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T.,
RA   Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R., Banerjee R.,
RA   Bryant S.P., Burford D.C., Burrill W.D., Clegg S.M., Dhami P.,
RA   Dovey O., Faulkner L.M., Gribble S.M., Langford C.F., Pandian R.D.,
RA   Porter K.M., Prigmore E.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000434718}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR   EMBL; AL137789; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL691452; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H0YE06; -.
DR   jPOST; H0YE06; -.
DR   PeptideAtlas; H0YE06; -.
DR   PRIDE; H0YE06; -.
DR   Ensembl; ENST00000529814; ENSP00000434718; ENSG00000203710.
DR   UCSC; uc057ozx.1; human.
DR   EuPathDB; HostDB:ENSG00000203710.10; -.
DR   HGNC; HGNC:2334; CR1.
DR   OpenTargets; ENSG00000203710; -.
DR   GeneTree; ENSGT00940000160375; -.
DR   ChiTaRS; CR1; human.
DR   Proteomes; UP000005640; Chromosome 1.
DR   Bgee; ENSG00000203710; Expressed in 135 organ(s), highest expression level in blood.
DR   ExpressionAtlas; H0YE06; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   CDD; cd00033; CCP; 9.
DR   InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR   InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR   Pfam; PF00084; Sushi; 9.
DR   SMART; SM00032; CCP; 9.
DR   SUPFAM; SSF57535; SSF57535; 9.
DR   PROSITE; PS50923; SUSHI; 9.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00302,
KW   ECO:0000256|SAAS:SAAS00887447}; Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|MaxQB:H0YE06,
KW   ECO:0000213|PeptideAtlas:H0YE06};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Sushi {ECO:0000256|PROSITE-ProRule:PRU00302};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     17       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        18    660       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5008415116.
FT   TRANSMEM    595    619       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       17     77       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN       78    139       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN      140    210       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN      212    269       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN      271    331       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN      332    394       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN      395    465       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN      469    529       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN      530    590       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DISULFID     19     62       {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT   DISULFID    242    269       {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT   DISULFID    273    316       {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT   DISULFID    302    329       {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT   DISULFID    471    514       {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT   DISULFID    500    527       {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT   DISULFID    532    575       {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT   DISULFID    561    588       {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSP00000434718}.
FT   NON_TER     660    660       {ECO:0000313|Ensembl:ENSP00000434718}.
SQ   SEQUENCE   660 AA;  72935 MW;  1214FAADE83D6A40 CRC64;
     XSLLAVVVLL ALPVAWGQCN APEWLPFARP TNLTDEFEFP IGTYLNYECR PGYSGRPFSI
     ICLKNSVWTG AKDRCRRKSC RNPPDPVNGM VHVIKGIQFG SQIKYSCTKG YRLIGSSSAT
     CIISGDTVIW DNETPICDRI PCGLPPTITN GDFISTNREN FHYGSVVTYR CNPGSGGRKV
     FELVGEPSIY CTSNDDQVGI WSGPAPQCII PNKCTPPNVE NGILVSDNRS LFSLNEVVEF
     RCQPGFVMKG PRRVKCQALN KWEPELPSCS RVCQPPPDVL HAERTQRDKD NFSPGQEVFY
     SCEPGYDLRG AASMRCTPQG DWSPAAPTCE VKSCDDFMGQ LLNGRVLFPV NLQLGAKVDF
     VCDEGFQLKG SSASYCVLAG MESLWNSSVP VCEQIFCPNP PAILNGRHTG TPFGDIPYGK
     EISYACDTHP DRGMTFNLIG ESSIRCTSDP QGNGVWSSPA PRCELSVPAA CPHPPKIQNG
     HYIGGHVSLY LPGMTISYIC DPGYLLVGKG FIFCTDQGIW SQLDHYCKEV NCSFPLFMNG
     ISKELEMKKV YHYGDYVTLK CEDGYTLEGS PWSQCQADDR WDPPLAKCTS RTHDALIVGT
     LSGTIFFILL IIFLSWIILK HRKGNNAHEN PKEVAIHLHS QGGSSVHPRT LQTNEENSRY
//