ID   H0YDT2_HUMAN            Unreviewed;       211 AA.
AC   H0YDT2;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   05-DEC-2018, entry version 42.
DE   SubName: Full=Cathepsin W {ECO:0000313|Ensembl:ENSP00000434267};
DE   Flags: Fragment;
GN   Name=CTSW {ECO:0000313|Ensembl:ENSP00000434267};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000434267, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000434267, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000434267}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase C1 family.
CC       {ECO:0000256|RuleBase:RU362133}.
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DR   EMBL; AP001201; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H0YDT2; -.
DR   SMR; H0YDT2; -.
DR   PeptideAtlas; H0YDT2; -.
DR   PRIDE; H0YDT2; -.
DR   Ensembl; ENST00000526034; ENSP00000434267; ENSG00000172543.
DR   UCSC; uc058drh.1; human.
DR   EuPathDB; HostDB:ENSG00000172543.7; -.
DR   HGNC; HGNC:2546; CTSW.
DR   OpenTargets; ENSG00000172543; -.
DR   GeneTree; ENSGT00940000161630; -.
DR   ChiTaRS; CTSW; human.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000172543; Expressed in 112 organ(s), highest expression level in leukocyte.
DR   ExpressionAtlas; H0YDT2; baseline and differential.
DR   GO; GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.
DR   InterPro; IPR033158; Cathepsin_W.
DR   InterPro; IPR038765; Papain_like_cys_pep_sf.
DR   InterPro; IPR013128; Peptidase_C1A.
DR   InterPro; IPR000668; Peptidase_C1A_C.
DR   InterPro; IPR013201; Prot_inhib_I29.
DR   PANTHER; PTHR12411; PTHR12411; 2.
DR   PANTHER; PTHR12411:SF101; PTHR12411:SF101; 2.
DR   Pfam; PF08246; Inhibitor_I29; 1.
DR   Pfam; PF00112; Peptidase_C1; 1.
DR   SMART; SM00848; Inhibitor_I29; 1.
DR   SUPFAM; SSF54001; SSF54001; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:H0YDT2,
KW   ECO:0000213|MaxQB:H0YDT2, ECO:0000213|PeptideAtlas:H0YDT2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|RuleBase:RU362133}.
FT   SIGNAL        1     20       {ECO:0000256|RuleBase:RU362133}.
FT   CHAIN        21    211       {ECO:0000256|RuleBase:RU362133}.
FT                                /FTId=PRO_5005398448.
FT   DOMAIN       41     98       Inhibitor_I29.
FT                                {ECO:0000259|SMART:SM00848}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSP00000434267}.
FT   NON_TER     211    211       {ECO:0000313|Ensembl:ENSP00000434267}.
SQ   SEQUENCE   211 AA;  23677 MW;  E05A18D07FF0CA8D CRC64;
     ALTAHPSCLL ALLVAGLAQG IRGPLRAQDL GPQPLELKEA FKLFQIQFNR SYLSPEEHAH
     RLDIFAHNLA QAQRLQEEDL GTAEFGVTPF SDLTEEEFGQ LYGYRRAAGG VPSMGREIRS
     EEPEESVPFS CDWRKVASAI SPIKDQKNCN CCWAMAAAGN IETLWRISFW DFVDVSVQGG
     LASEKDYPFQ GKVRAHRCHP KKYQKVAWIQ D
//