ID H0YCV9_HUMAN Unreviewed; 277 AA. AC H0YCV9; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 20-JUN-2018, sequence version 2. DT 13-FEB-2019, entry version 55. DE SubName: Full=CD44 antigen {ECO:0000313|Ensembl:ENSP00000432405}; DE Flags: Fragment; GN Name=CD44 {ECO:0000313|Ensembl:ENSP00000432405}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000432405, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000432405, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16554811; DOI=10.1038/nature04632; RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., RA Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T., RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G., RA Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C., RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., RA Hattori M., Rogers J., Lander E.S., Sakaki Y.; RT "Human chromosome 11 DNA sequence and analysis including novel gene RT identification."; RL Nature 440:497-500(2006). RN [2] {ECO:0000213|PubMed:18669648} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=18669648; DOI=10.1073/pnas.0805139105; RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., RA Elledge S.J., Gygi S.P.; RT "A quantitative atlas of mitotic phosphorylation."; RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). RN [3] {ECO:0000213|PubMed:19690332} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19690332; DOI=10.1126/scisignal.2000007; RA Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K., RA Rodionov V., Han D.K.; RT "Quantitative phosphoproteomic analysis of T cell receptor signaling RT reveals system-wide modulation of protein-protein interactions."; RL Sci. Signal. 2:ra46-RA46(2009). RN [4] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [5] {ECO:0000313|Ensembl:ENSP00000432405} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. RN [6] {ECO:0000213|PubMed:23186163} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=23186163; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). RN [7] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00323}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL133330; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL136989; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL356215; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H0YCV9; -. DR SwissPalm; H0YCV9; -. DR jPOST; H0YCV9; -. DR PeptideAtlas; H0YCV9; -. DR PRIDE; H0YCV9; -. DR Ensembl; ENST00000525211; ENSP00000432405; ENSG00000026508. DR UCSC; uc058aip.1; human. DR EuPathDB; HostDB:ENSG00000026508.16; -. DR HGNC; HGNC:1681; CD44. DR OpenTargets; ENSG00000026508; -. DR eggNOG; ENOG410IZCP; Eukaryota. DR eggNOG; ENOG4111S6T; LUCA. DR GeneTree; ENSGT00530000063822; -. DR ChiTaRS; CD44; human. DR Proteomes; UP000005640; Chromosome 11. DR Bgee; ENSG00000026508; Expressed in 228 organ(s), highest expression level in parotid gland. DR ExpressionAtlas; H0YCV9; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:InterPro. DR GO; GO:0005540; F:hyaluronic acid binding; IEA:InterPro. DR GO; GO:0007155; P:cell adhesion; IEA:InterPro. DR Gene3D; 3.10.100.10; -; 1. DR InterPro; IPR016186; C-type_lectin-like/link_sf. DR InterPro; IPR001231; CD44_antigen. DR InterPro; IPR016187; CTDL_fold. DR InterPro; IPR000538; Link_dom. DR PANTHER; PTHR10225:SF6; PTHR10225:SF6; 1. DR Pfam; PF00193; Xlink; 1. DR PRINTS; PR00658; CD44. DR PRINTS; PR01265; LINKMODULE. DR SMART; SM00445; LINK; 1. DR SUPFAM; SSF56436; SSF56436; 1. DR PROSITE; PS01241; LINK_1; 1. DR PROSITE; PS50963; LINK_2; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|EPD:H0YCV9, KW ECO:0000213|MaxQB:H0YCV9, ECO:0000213|PeptideAtlas:H0YCV9}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 277 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015303732. FT DOMAIN 32 120 Link. {ECO:0000259|PROSITE:PS50963}. FT NON_TER 277 277 {ECO:0000313|Ensembl:ENSP00000432405}. SQ SEQUENCE 277 AA; 30625 MW; F4B64F834BCA8C1A CRC64; MDKFWWHAAW GLCLVPLSLA QIDLNITCRF AGVFHVEKNG RYSISRTEAA DLCKAFNSTL PTMAQMEKAL SIGFETCRYG FIEGHVVIPR IHPNSICAAN NTGVYILTSN TSQYDTYCFN ASAPPEEDCT SVTDLPNAFD GPITITIVNR DGTRYVQKGE YRTNPEDIYP SNPTDDDVSS GSSSERSSTS GGYIFYTFST VHPIPDEDSP WITDSTDRIP ATTASAHTSH PMQGRTTPSP EDSSWTDFFN PISHPMGRGH QAGRRMDMDS SHSITLQ //