ID   H0YCV0_HUMAN            Unreviewed;       228 AA.
AC   H0YCV0;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   16-JAN-2019, entry version 43.
DE   RecName: Full=Alpha-1,3-glucosyltransferase {ECO:0000256|RuleBase:RU363110};
DE            EC=2.4.1.- {ECO:0000256|RuleBase:RU363110};
DE   Flags: Fragment;
GN   Name=ALG8 {ECO:0000313|Ensembl:ENSP00000432381};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000432381, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000432381, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000432381}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- PATHWAY: Protein modification; protein glycosylation.
CC       {ECO:0000256|RuleBase:RU363110}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|RuleBase:RU363110}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU363110}.
CC   -!- SIMILARITY: Belongs to the ALG6/ALG8 glucosyltransferase family.
CC       {ECO:0000256|RuleBase:RU363110}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU363110}.
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DR   EMBL; AP002520; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H0YCV0; -.
DR   jPOST; H0YCV0; -.
DR   MaxQB; H0YCV0; -.
DR   PeptideAtlas; H0YCV0; -.
DR   PRIDE; H0YCV0; -.
DR   Ensembl; ENST00000530608; ENSP00000432381; ENSG00000159063.
DR   UCSC; uc058fvo.1; human.
DR   EuPathDB; HostDB:ENSG00000159063.12; -.
DR   HGNC; HGNC:23161; ALG8.
DR   OpenTargets; ENSG00000159063; -.
DR   GeneTree; ENSGT00940000153733; -.
DR   UniPathway; UPA00378; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000159063; Expressed in 215 organ(s), highest expression level in right testis.
DR   ExpressionAtlas; H0YCV0; baseline and differential.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0042283; F:dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity; IEA:InterPro.
DR   GO; GO:0006490; P:oligosaccharide-lipid intermediate biosynthetic process; IEA:InterPro.
DR   GO; GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR039487; ALG8.
DR   InterPro; IPR004856; Glyco_trans_ALG6/ALG8.
DR   PANTHER; PTHR12413; PTHR12413; 2.
DR   PANTHER; PTHR12413:SF2; PTHR12413:SF2; 2.
DR   Pfam; PF03155; Alg6_Alg8; 2.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Endoplasmic reticulum {ECO:0000256|RuleBase:RU363110};
KW   Glycosyltransferase {ECO:0000256|RuleBase:RU363110};
KW   Membrane {ECO:0000256|RuleBase:RU363110};
KW   Proteomics identification {ECO:0000213|MaxQB:H0YCV0,
KW   ECO:0000213|PeptideAtlas:H0YCV0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transferase {ECO:0000256|RuleBase:RU363110};
KW   Transmembrane {ECO:0000256|RuleBase:RU363110};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU363110}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19    228       Alpha-1,3-glucosyltransferase.
FT                                {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003546670.
FT   TRANSMEM     63     80       Helical. {ECO:0000256|RuleBase:RU363110}.
FT   TRANSMEM     87    111       Helical. {ECO:0000256|RuleBase:RU363110}.
FT   TRANSMEM    131    151       Helical. {ECO:0000256|RuleBase:RU363110}.
FT   TRANSMEM    163    185       Helical. {ECO:0000256|RuleBase:RU363110}.
FT   TRANSMEM    191    210       Helical. {ECO:0000256|RuleBase:RU363110}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSP00000432381}.
SQ   SEQUENCE   228 AA;  25719 MW;  A375ACAA91D37836 CRC64;
     XGLVVFLVSA LSLGPFLALN QLPQVFSRLF PFKRGLCHAY WAPNFWALYN ALDKVLSVIG
     PRGFLRCLTL CALSSFMFGW HVHEKAILLA ILPMSLLSVG KAGDASIFLI LTTTGHYSLF
     PLLFTAPELP IKILLMLLFT IYSISSLKTL FRKEKPLFNW METFYLLGLG PLEVCCEFVF
     PFTSWKVKYP FIPLLLTSVY CAVGITYAWF KLYVSVLIDS AIGKTKKQ
//