ID   H0YC18_HUMAN            Unreviewed;       173 AA.
AC   H0YC18;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   12-SEP-2018, entry version 43.
DE   SubName: Full=Meckelin {ECO:0000313|Ensembl:ENSP00000430740};
DE   Flags: Fragment;
GN   Name=TMEM67 {ECO:0000313|Ensembl:ENSP00000430740};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000430740, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000430740, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S.,
RA   Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A.,
RA   Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA   Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T.,
RA   Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K.,
RA   DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Glockner G.,
RA   Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B.,
RA   Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C.,
RA   O'Leary S.B., O'Neill K., Parker S.C., Polley A., Raymond C.K.,
RA   Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R.,
RA   Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K.,
RA   Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q.,
RA   Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N.,
RA   Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000430740}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
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DR   EMBL; AC010834; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H0YC18; -.
DR   MaxQB; H0YC18; -.
DR   PeptideAtlas; H0YC18; -.
DR   PRIDE; H0YC18; -.
DR   Ensembl; ENST00000521517; ENSP00000430740; ENSG00000164953.
DR   UCSC; uc064opd.1; human.
DR   EuPathDB; HostDB:ENSG00000164953.15; -.
DR   HGNC; HGNC:28396; TMEM67.
DR   OpenTargets; ENSG00000164953; -.
DR   eggNOG; KOG4611; Eukaryota.
DR   eggNOG; ENOG410XQCG; LUCA.
DR   GeneTree; ENSGT00390000010606; -.
DR   ChiTaRS; TMEM67; human.
DR   Proteomes; UP000005640; Chromosome 8.
DR   Bgee; ENSG00000164953; Expressed in 154 organ(s), highest expression level in buccal mucosa cell.
DR   ExpressionAtlas; H0YC18; baseline and differential.
DR   GO; GO:0036038; C:MKS complex; IEA:InterPro.
DR   GO; GO:0060271; P:cilium assembly; IEA:InterPro.
DR   GO; GO:0010826; P:negative regulation of centrosome duplication; IEA:InterPro.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR019170; Meckelin.
DR   PANTHER; PTHR21274; PTHR21274; 1.
DR   SUPFAM; SSF57184; SSF57184; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:H0YC18,
KW   ECO:0000213|PeptideAtlas:H0YC18};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     34       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        35    173       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003545873.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSP00000430740}.
FT   NON_TER     173    173       {ECO:0000313|Ensembl:ENSP00000430740}.
SQ   SEQUENCE   173 AA;  18631 MW;  C1FC69ECC1251E57 CRC64;
     XRGGAGVAMA VWSLLSARAV TAFLLLFLPR FLQAQTFSFP FQQPEKCDNN QYFDISALSC
     VPCGANQRQD ARGTSCVCLP GFQMISNNGG PAIICKKCPE NMKGVTEDGW NCISCPSDLT
     AEGKCHCPIG HILVERDING TLLSQATCEL CDGNENSFMV VNALGDRQGD YVS
//